Cyclotides Suppress Human T-Lymphocyte Proliferation by an Interleukin 2-Dependent Mechanism

Cyclotides are a diverse and abundant group of ribosomally synthesized plant peptides containing a unique cyclic cystine-knotted topology that confers them with remarkable stability. Kalata B1, a representative member of this family of mini-proteins, has been found to inhibit the proliferation of hu...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e68016
Hauptverfasser:	Gründemann, Carsten, Thell, Kathrin, Lengen, Karin, Garcia-Käufer, Manuel, Huang, Yen-Hua, Huber, Roman, Craik, David J, Schabbauer, Gernot, Gruber, Christian W
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative medicine Biological activity Biological effects Cell cycle Cell growth Cell proliferation Cell Proliferation - drug effects Cells, Cultured Cyclosporin A Cyclotides - pharmacology Cystine Cytokines Degranulation Environmental health Gene expression Health sciences Humans Immune system Immunology Immunosuppressive agents Interferon Interleukin 2 Interleukin-2 - metabolism Leukocytes (mononuclear) Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - drug effects Lymphocyte Activation - drug effects Lymphocytes Lymphocytes T Mutants Peptides Peripheral blood mononuclear cells Pharmacology Physiology Proteins Rheumatoid arthritis Rubiaceae Rubiaceae - chemistry Signaling Synthesis T-Lymphocytes - cytology T-Lymphocytes - drug effects Topology Tumor necrosis factor-α Violaceae γ-Interferon
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