"Salvage microbiology": detection of bacteria directly from clinical specimens following initiation of antimicrobial treatment

PCR coupled with electrospray ionization mass spectrometry (ESI-MS) is a diagnostic approach that has demonstrated the capacity to detect pathogenic organisms from culture negative clinical samples after antibiotic treatment has been initiated. [1] We describe the application of PCR/ESI-MS for detec...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66349-e66349
Hauptverfasser:	Farrell, John J, Sampath, Rangarajan, Ecker, David J, Bonomo, Robert A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Agreements Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Antiinfectives and antibacterials Bacteria Bacteria - drug effects Bacteria - isolation & purification Bacterial infections Bacterial Infections - drug therapy Biology Carbapenems - pharmacology Care and treatment Child Coagulase Decision Making Diagnostic systems Drug dosages Drug Resistance, Bacterial Female Flora Health aspects Humans Identification Identification methods Infection Infections Ionization Knee Laboratories Male Mass spectrometry Mass spectroscopy Mechanical knees Medical schools Medicine Meningitis Microbiological Techniques - methods Microbiology Middle Aged Mortality Pathogens Patients Pneumonia Polymerase Chain Reaction Prostheses Prostheses and implants Prosthesis-Related Infections - drug therapy Prosthetics Salvage Scientific imaging Spectrometry, Mass, Electrospray Ionization Yeast
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