Gene Deficiency in Activating Fcγ Receptors Influences the Macrophage Phenotypic Balance and Reduces Atherosclerosis in Mice

Immunity contributes to arterial inflammation during atherosclerosis. Oxidized low-density lipoproteins induce an autoimmune response characterized by specific antibodies and immune complexes in atherosclerotic patients. We hypothesize that specific Fcγ receptors for IgG constant region participate...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66754-e66754
Hauptverfasser:	Mallavia, Beñat, Oguiza, Ainhoa, Lopez-Franco, Oscar, Recio, Carlota, Ortiz-Muñoz, Guadalupe, Lazaro, Iolanda, Lopez-Parra, Virginia, Egido, Jesus, Gomez-Guerrero, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibody response Antigen-antibody complexes Apolipoproteins E - deficiency Apolipoproteins E - genetics Apoptosis Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerosis - genetics Atherosclerosis - mortality Atherosclerosis - physiopathology Biology Blood Bone marrow Bone Marrow Transplantation Collagen Collagen - metabolism Constant region Cytokines Disease Disease Models, Animal Foams Gene expression Genes Hyperlipidemias - pathology Immunity Immunoglobulin G Inflammation Lesions Lipids Lipids - blood Lipoproteins Lipoproteins, LDL - blood Lipoproteins, LDL - immunology Lymphocytes Lymphocytes T Macrophages Macrophages - cytology Macrophages - metabolism Male Medicine Mice Mice, Inbred C57BL Mice, Knockout Monocytes Muscles Nephrology Nitric oxide Oxidative stress Phenotype Plaque, Atherosclerotic - pathology Proteins Receptor density Receptors Receptors, IgG - deficiency Receptors, IgG - genetics Regulation Rodents Serum lipids Signaling Smooth muscle Stem cell transplantation Stem cells T-Lymphocytes - cytology T-Lymphocytes - metabolism Transplantation Tumor necrosis factor-TNF
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