High Fat Diet Induces Liver Steatosis and Early Dysregulation of Iron Metabolism in Rats

This paper is dedicated to the memory of our wonderful colleague Professor Alfredo Colonna, who passed away the same day of its acceptance. Fatty liver accumulation, inflammatory process and insulin resistance appear to be crucial in non-alcoholic fatty liver disease (NAFLD), nevertheless emerging f...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66570
Hauptverfasser:	Meli, Rosaria, Mattace Raso, Giuseppina, Irace, Carlo, Simeoli, Raffaele, Di Pascale, Antonio, Paciello, Orlando, Pagano, Teresa Bruna, Calignano, Antonio, Colonna, Alfredo, Santamaria, Rita
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antigens, CD - metabolism Biology Blood proteins Carbohydrates Diet Dietary Fats - adverse effects Dietary Fats - pharmacology Disease Models, Animal Down-regulation Fatty liver Fatty Liver - chemically induced Fatty Liver - complications Fatty Liver - metabolism Fatty Liver - pathology Ferritin Gene expression Hep G2 Cells Hepatocytes Hepatology Hepcidin High fat diet Homeostasis Humans Hypoxia Impairment Inflammation Insulin Insulin resistance Interleukin 6 Iron Iron - metabolism Iron content Iron Overload - etiology Iron Overload - metabolism Iron Overload - pathology Iron regulatory protein Iron Regulatory Protein 1 - metabolism Kinases Laboratories Leptin Liver Liver - metabolism Liver - pathology Liver diseases Male Medicine Metabolism Molecular modelling Oils & fats Oxidative stress Peptides Pharmacy Physiological aspects Protein transport Proteins Rats Rats, Sprague-Dawley Receptors, Transferrin - metabolism Rodents Steatosis Transaminases Transferrin Tumor necrosis factor-α Unbalance Veterinary medicine
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