Myocardial Ablation of G Protein-Coupled Receptor Kinase 2 (GRK2) Decreases Ischemia/Reperfusion Injury through an Anti-Intrinsic Apoptotic Pathway

Studies from our lab have shown that decreasing myocardial G protein-coupled receptor kinase 2 (GRK2) activity and expression can prevent heart failure progression after myocardial infarction. Since GRK2 appears to also act as a pro-death kinase in myocytes, we investigated the effect of cardiomyocy...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66234-e66234
Hauptverfasser:	Fan, Qian, Chen, Mai, Zuo, Lin, Shang, Xiying, Huang, Maggie Z, Ciccarelli, Michele, Raake, Philip, Brinks, Henriette, Chuprun, Kurt J, Dorn, 2nd, Gerald W, Koch, Walter J, Gao, Erhe
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Ablation (Surgery) AKT protein Animals Apoptosis b-Adrenergic-receptor kinase Bcl-2 protein Bcl-x protein bcl-X Protein - metabolism Biology Cardiomyocytes Caspase Caspase-3 Caspase-8 Coronary artery Cytochrome Cytochrome c Cytochromes c - metabolism Echocardiography G proteins G-Protein-Coupled Receptor Kinase 2 - antagonists & inhibitors G-Protein-Coupled Receptor Kinase 2 - genetics G-Protein-Coupled Receptor Kinase 2 - metabolism Gene expression Heart Heart attack Heart diseases Heart failure Hemodynamics Hemodynamics - drug effects House mouse Injury prevention Ischemia Isoproterenol - pharmacology Kinases Male Medicine Membrane proteins Mice Mice, Inbred C57BL Mice, Knockout Mitochondria mRNA Myocardial infarction Myocardial Infarction - metabolism Myocardial Infarction - pathology Myocardial ischemia Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - enzymology Myocardium - pathology Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Oxidative Stress Prevention Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Reperfusion Retirement planning RNA Interference Rodents Up-Regulation
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