Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (γ) radiation

There is evidence for a role of ionizing radiation in cardiovascular diseases. The goal of this work was to identify changes in oxidative and nitrative stress pathways and the status of the endothelinergic system during progression of atherosclerosis in ApoE-deficient mice after single and repeated...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65486
Hauptverfasser:	Kumarathasan, Prem, Vincent, Renaud, Blais, Erica, Saravanamuthu, Anu, Gupta, Pallavi, Wyatt, Heather, Mitchel, Ronald, Hannan, Mohammed, Trivedi, Akilesh, Whitman, Stewart
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxydeoxyguanosine Acids Animals Apolipoprotein E Apolipoproteins Apolipoproteins E - deficiency Apolipoproteins E - genetics Arteriosclerosis Atherosclerosis Atherosclerosis - blood Background radiation Biochemistry Biology Cancer therapies Cardiovascular disease Cardiovascular diseases Cell cycle Chemistry Cholesterol Cholesterol - blood Chronic exposure Cobalt Cobalt Radioisotopes Deoxyguanosine - analogs & derivatives Deoxyguanosine - blood Dihydroxyphenylalanine Dinoprost - analogs & derivatives Dinoprost - blood DNA Damage Endothelin 1 Endothelin 3 Endothelins Endothelins - blood Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Endothelium, Vascular - radiation effects Environmental health Exposure Female Gene expression Heart Heart diseases Hypertension Ionizing radiation Laboratories Levodopa Levodopa - blood Lipid Peroxidation Medicine Mice Mice, 129 Strain Mice, Inbred C57BL Mortality Mutation Nitrates Nitrites - blood Nitrotyrosine Oxidative stress Oxidative Stress - radiation effects Peptides Physics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Post-radiation Proteomics Radiation Radiation dosage Radiation Injuries, Experimental - blood Radiation therapy Radiotherapy Rodents Science Sodium Toxicology Tyrosine - blood
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