Contribution of pannexin1 to experimental autoimmune encephalomyelitis

Pannexin1 (Panx1) is a plasma membrane channel permeable to relatively large molecules, such as ATP. In the central nervous system (CNS) Panx1 is found in neurons and glia and in the immune system in macrophages and T-cells. We tested the hypothesis that Panx1-mediated ATP release contributes to exp...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66657-e66657
Hauptverfasser:	Lutz, Sarah E, González-Fernández, Estibaliz, Ventura, Juan Carlos Chara, Pérez-Samartín, Alberto, Tarassishin, Leonid, Negoro, Hiromitsu, Patel, Naman K, Suadicani, Sylvia O, Lee, Sunhee C, Matute, Carlos, Scemes, Eliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Analysis Animal models Animal tissues Animals Apoptosis ATP Base Sequence Biology Central nervous system Chronic illnesses Connexins - genetics Connexins - physiology Cytokines Development and progression DNA Primers Encephalomyelitis Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - physiopathology Enzyme-Linked Immunosorbent Assay Experimental allergic encephalomyelitis Gene disruption Health aspects Immune system Inflammasomes Inflammation Inhibition Interleukin-1beta - metabolism Ischemia Laboratories Lesions Lymphocytes T Macrophages Macrophages - metabolism Medical schools Medicine Mefloquine Mice Mice, Knockout Multiple sclerosis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neuronal-glial interactions Neurosciences Paralysis Pathology Pharmacology Real-Time Polymerase Chain Reaction Receptors, Purinergic P2X7 - metabolism Rodents Spinal cord Spleen - metabolism Spleen - pathology T cells Tuberculosis Urology
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