Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment
The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model,...
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| Veröffentlicht in: | PloS one 2013-06, Vol.8 (6), p.e66494 |
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| creator | Jrad-Lamine, Aicha Henry-Berger, Joelle Damon-Soubeyrand, Christelle Saez, Fabrice Kocer, Ayhan Janny, Laurent Pons-Rejraji, Hanae Munn, David H Mellor, Andrew L Gharbi, Najoua Cadet, Rémi Guiton, Rachel Aitken, Robert J Drevet, Joël R |
| description | The epididymis maintains a state of immune tolerance towards spermatozoa while also protecting them and itself against infection and acute inflammation. The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1(-/-) animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed. |
| doi_str_mv | 10.1371/journal.pone.0066494 |
| format | Article |
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The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. Despite this more pronounced inflammatory state, Ido1(-/-) animals succeed in preserving the local epididymal immune situation due to the activation of compensatory mechanisms that are discussed.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0066494</identifier><identifier>PMID: 23840489</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adaptive Immunity ; Analysis ; Animals ; Biology ; Chemokines ; Chemokines - metabolism ; Cytokines ; Enzymes ; Epididymis ; Epididymis - enzymology ; Epididymis - immunology ; Health aspects ; Helper cells ; Immunological tolerance ; Immunology ; Immunosuppression ; Immunotherapy ; Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology ; Inflammation ; Inflammatory response ; Interleukins - metabolism ; Intermediates ; Kynurenine - metabolism ; Laboratories ; Life Sciences ; Lymphocytes ; Lymphocytes T ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Knockout ; Rodent control ; Spermatogenesis ; Spermatozoa ; T-Lymphocytes - immunology ; Tryptophan 2,3-dioxygenase ; Wildlife conservation</subject><ispartof>PloS one, 2013-06, Vol.8 (6), p.e66494</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Jrad-Lamine et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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The immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (Ido1) participates in this delicate local equilibrium. Using the mouse Ido1(-/-) model, we show here that the absence of IDO1 expression leads in the epididymis but not in serum to (1) an increase in the inflammatory state as evidenced by changes in the content of cytokines and chemokines, (2) the engagement of a Th1-driven inflammatory response as evidenced by changes in the Th17/Treg as well as Th1/Th2 equilibria, as well as (3) differences in the content of lipid intermediates classically involved in inflammation. 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| ispartof | PloS one, 2013-06, Vol.8 (6), p.e66494 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1370183788 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adaptive Immunity Analysis Animals Biology Chemokines Chemokines - metabolism Cytokines Enzymes Epididymis Epididymis - enzymology Epididymis - immunology Health aspects Helper cells Immunological tolerance Immunology Immunosuppression Immunotherapy Indoleamine-Pyrrole 2,3,-Dioxygenase - physiology Inflammation Inflammatory response Interleukins - metabolism Intermediates Kynurenine - metabolism Laboratories Life Sciences Lymphocytes Lymphocytes T Male Mice Mice, Inbred BALB C Mice, Knockout Rodent control Spermatogenesis Spermatozoa T-Lymphocytes - immunology Tryptophan 2,3-dioxygenase Wildlife conservation |
| title | Indoleamine 2,3-dioxygenase 1 (ido1) is involved in the control of mouse caput epididymis immune environment |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T06%3A01%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Indoleamine%202,3-dioxygenase%201%20(ido1)%20is%20involved%20in%20the%20control%20of%20mouse%20caput%20epididymis%20immune%20environment&rft.jtitle=PloS%20one&rft.au=Jrad-Lamine,%20Aicha&rft.date=2013-06-20&rft.volume=8&rft.issue=6&rft.spage=e66494&rft.pages=e66494-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0066494&rft_dat=%3Cgale_plos_%3EA478192429%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1370183788&rft_id=info:pmid/23840489&rft_galeid=A478192429&rft_doaj_id=oai_doaj_org_article_8ab5a029b0a84e7cb1dec43d517f30e3&rfr_iscdi=true |