Designed azolopyridinium salts block protective antigen pores in vitro and protect cells from anthrax toxin

Several intracellular acting bacterial protein toxins of the AB-type, which are known to enter cells by endocytosis, are shown to produce channels. This holds true for protective antigen (PA), the binding component of the tripartite anthrax-toxin of Bacillus anthracis. Evidence has been presented th...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66099-e66099
Hauptverfasser:	Beitzinger, Christoph, Bronnhuber, Anika, Duscha, Kerstin, Riedl, Zsuzsanna, Huber-Lang, Markus, Benz, Roland, Hajós, György, Barth, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Analysis Animals Anthrax Anti-Bacterial Agents - pharmacology Antigens Antigens, Bacterial - physiology Bacillus anthracis Bacillus anthracis - immunology Bacteria Bacterial proteins Bacterial Toxins - antagonists & inhibitors Binding Biology Cell Line Cell Survival - drug effects Channel pores Channels Chloroquine Clostridium botulinum Drugs E coli Edema Endocytosis Enzymes Escherichia coli Experiments Health aspects Imidazoles - pharmacology In vivo methods and tests Intoxication Kinases Kinetics Lethal factor Lipid Bilayers Macrophages Membrane Potentials Membranes Mice Models, Biological Noise Organic chemistry Protective antigen Protein Binding Protein Transport Proteins Pyridines - pharmacology Salts Titrimetry Toxicology Toxins Translocation Tumor Necrosis Factor-alpha - secretion
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