RNA-Seq Differentiates Tumour and Host mRNA Expression Changes Induced by Treatment of Human Tumour Xenografts with the VEGFR Tyrosine Kinase Inhibitor Cediranib

Pre-clinical models of tumour biology often rely on propagating human tumour cells in a mouse. In order to gain insight into the alignment of these models to human disease segments or investigate the effects of different therapeutics, approaches such as PCR or array based expression profiling are of...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66003
Hauptverfasser:	Bradford, James R, Farren, Matthew, Powell, Steve J, Runswick, Sarah, Weston, Susie L, Brown, Helen, Delpuech, Oona, Wappett, Mark, Smith, Neil R, Carr, T Hedley, Dry, Jonathan R, Gibson, Neil J, Barry, Simon T
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Animal models Animals Antineoplastic agents Arrays Bioinformatics Biology Biomarkers Blood vessels Cancer Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - genetics Cell cycle Cell Cycle - drug effects Cell Hypoxia - drug effects Cell Line, Tumor Compartments Computational Biology Computer applications DNA microarrays Endothelium Enzyme inhibitors Gene expression Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic - drug effects Gene Regulatory Networks - drug effects Gene sequencing Genes Genetic research Genomes Humans Hybridization Hypoxia Inflammation Inflammatory response Inhibitors Kinases Lung Neoplasms - drug therapy Lung Neoplasms - genetics Medicine Messenger RNA Mice Oligonucleotide Array Sequence Analysis - methods Oncology Ontology Pharmaceuticals Phenols (Class of compounds) Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology Protein-tyrosine kinase receptors Quinazolines - administration & dosage Quinazolines - pharmacology Real-Time Polymerase Chain Reaction Reduction Ribonucleic acid RNA RNA sequencing Sequence Analysis, RNA - methods Species Species Specificity Transcription Tumors Tyrosine Vascular endothelial growth factor Vascular endothelial growth factor receptors Xenograft Model Antitumor Assays Xenografts
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