A Transient Upregulation of Glutamine Synthetase in the Dentate Gyrus Is Involved in Epileptogenesis Induced by Amygdala Kindling in the Rat

Reduction of glutamine synthetase (GS) function is closely related to established epilepsy, but little is known regarding its role in epileptogenesis. The present study aimed to elucidate the functional changes of GS in the brain and its involvement in epileptogenesis using the amygdala kindling mod...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66885-e66885
Hauptverfasser:	Sun, Hong-Liu, Zhang, Shi-Hong, Zhong, Kai, Xu, Zheng-Hao, Feng, Bo, Yu, Jie, Fang, Qi, Wang, Shuang, Wu, Deng-Chang, Zhang, Jian-Min, Chen, Zhong
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Amygdala - physiopathology Animals Biology Brain Convulsions & seizures Dentate gyrus Dentate Gyrus - enzymology Dentate Gyrus - physiopathology Electrical stimuli Enzymes Epilepsy Epilepsy - enzymology Epilepsy - physiopathology Glutamate-ammonia ligase Glutamate-Ammonia Ligase - metabolism Glutamine Health aspects Hospitals Kindling Kindling, Neurologic Laboratory animals Ligases Male Medicine Methionine miRNA Neurobiology Neurosciences Pentylenetetrazole Pharmaceutical sciences Pharmacology Rats Rats, Sprague-Dawley Ribonucleic acid RNA Rodents Seizing Seizures Seizures (Medicine) Up-Regulation
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