Genome-Wide Gene Expression Profiling Revealed a Critical Role for GATA3 in the Maintenance of the Th2 Cell Identity

Functionally polarized CD4+ T helper (Th) cells such as Th1, Th2 and Th17 cells are central to the regulation of acquired immunity. However, the molecular mechanisms governing the maintenance of the polarized functions of Th cells remain unclear. GATA3, a master regulator of Th2 cell differentiation...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66468-e66468
Hauptverfasser:	Sasaki, Tetsuya, Onodera, Atsushi, Hosokawa, Hiroyuki, Watanabe, Yukiko, Horiuchi, Shu, Yamashita, Junji, Tanaka, Hitoshi, Ogawa, Yasumasa, Suzuki, Yutaka, Nakayama, Toshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biology CD4 antigen Cell differentiation Chromatin Chromatin remodeling Continuity (mathematics) Cytokines Cytokines - genetics Deoxyribonucleic acid DNA DNA fingerprinting Effector cells GATA-3 protein GATA3 Transcription Factor - genetics GATA3 Transcription Factor - metabolism Gene expression Gene Expression Profiling Gene Knockdown Techniques Gene loci Genes Genomes Genomics Helper cells Immunity Immunologic Memory Immunological memory Immunology Laboratories Lymphocytes Lymphocytes T Medicine Mice Mice, Inbred C57BL Molecular modelling Pharmaceuticals Receptors, Cytokine - genetics RNA, Small Interfering - genetics Th2 Cells - cytology Th2 Cells - metabolism Transcription factors
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