Gene Dosage Effects at the Imprinted Gnas Cluster

Genomic imprinting results in parent-of-origin-dependent monoallelic gene expression. Early work showed that distal mouse chromosome 2 is imprinted, as maternal and paternal duplications of the region (with corresponding paternal and maternal deficiencies) give rise to different anomalous phenotypes...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65639-e65639
Hauptverfasser:	Ball, Simon T, Kelly, Michelle L, Robson, Joan E, Turner, Martin D, Harrison, Jackie, Jones, Lynn, Napper, Diane, Beechey, Colin V, Hough, Tertius, Plagge, Antonius, Cattanach, Bruce M, Cox, Roger D, Peters, Jo
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorptiometry, Photon Animal tissues Animals Animals, Newborn Biology Book publishing Chromogranins - genetics Chromosome 2 Chromosomes Clusters Councils Defects Dosage Edema Epigenetics Gene Dosage Gene expression Genetics Genomic Imprinting Growth Disorders Growth rate GTP-Binding Protein alpha Subunits, Gs - genetics Hyperactivity Hypoglycemia Imprinting Medical research Mice Multigene Family Mutation Neonates Newborn babies Proteins Reproduction (copying) Science Transcription
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