The impact of a ligand binding on strand migration in the SAM-I riboswitch

Riboswitches sense cellular concentrations of small molecules and use this information to adjust synthesis rates of related metabolites. Riboswitches include an aptamer domain to detect the ligand and an expression platform to control gene expression. Previous structural studies of riboswitches larg...

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Veröffentlicht in:	PLoS computational biology 2013-05, Vol.9 (5), p.e1003069-e1003069
Hauptverfasser:	Huang, Wei, Kim, Joohyun, Jha, Shantenu, Aboul-ela, Fareed
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Chemistry Cluster Analysis Computational Biology - methods Gene expression Hydrogen Bonding Ligands Ligands (Biochemistry) Metabolites Migration Models, Genetic Molecular Dynamics Simulation Molecular genetics Nucleic Acid Conformation Physiological aspects Protein binding Proteins Riboswitch - genetics RNA sequencing RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism S-Adenosylmethionine - chemistry S-Adenosylmethionine - genetics S-Adenosylmethionine - metabolism Simulation
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