Immunization of aged pigs with attenuated pseudorabies virus vaccine combined with CpG oligodeoxynucleotide restores defective Th1 immune responses

Attempts to immunize aged subjects often result in the failure to elicit a protective immune response. Murine model studies have shown that oligonucleotides containing CpG motifs (CpG ODN) can stimulate immune system in aged mice as effectively as in young mice. Since many physiological and pathophy...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65536-e65536
Hauptverfasser:	Ming, Feiping, Yang, Jun, Chu, Pinpin, Ma, Miaopeng, Shi, Juqing, Cai, Haiming, Huang, Chaoyuan, Li, Huazhou, Jiang, Zhenggu, Wang, Houguang, Wang, Weifang, Zhang, Shuiqing, Zhang, Linghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic Age Age Factors Analysis Animal models Animals Antibodies, Viral - blood Antibodies, Viral - immunology Anticoagulants Antigens Aujeszky's disease Biology Biotechnology Blood Blood tests CD4 antigen CD8 antigen Cell activation Combined vaccines CpG islands Cytokines Cytokines - biosynthesis Defects Enzyme-linked immunosorbent assay Ethylenediaminetetraacetic acids Evacuation routing Heparin Herpesvirus 1, Suid - immunology Hogs Immune response Immune system Immunization Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulins Immunology Immunophenotyping Influenza Laboratories Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Life sciences Lymphocytes Lymphocytes T Medical research Medicine Mice Oligodeoxyribonucleotides - immunology Oligonucleotides Peripheral blood mononuclear cells Phenotype Physiology Pseudorabies - immunology Pseudorabies - prevention & control Pseudorabies Vaccines - administration & dosage Pseudorabies Vaccines - immunology Rodents Swine T cells Th1 Cells - immunology Tubes Vaccination Vaccines Vaccines, Attenuated Veterinary Science Viral infections Viruses
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