Monocarboxylate transporter 8 modulates the viability and invasive capacity of human placental cells and fetoplacental growth in mice

Monocarboxylate transporter 8 (MCT8) is a well-established thyroid hormone (TH) transporter. In humans, MCT8 mutations result in changes in circulating TH concentrations and X-linked severe global neurodevelopmental delay. MCT8 is expressed in the human placenta throughout gestation, with increased...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65402-e65402
Hauptverfasser:	Vasilopoulou, Elisavet, Loubière, Laurence S, Heuer, Heike, Trajkovic-Arsic, Marija, Darras, Veerle M, Visser, Theo J, Lash, Gendie E, Whitley, Guy S, McCabe, Christopher J, Franklyn, Jayne A, Kilby, Mark D, Chan, Shiao Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Analysis of Variance Animals Apoptosis - physiology Biology Cell Movement - physiology Cell Proliferation Cells, Cultured Concentration (composition) Endocrinology England Female Fetuses Genes Gestation Humans Insulin-like growth factors Medicine Membrane Transport Proteins - genetics Mice Mice, Knockout Monocarboxylic Acid Transporters - metabolism Morphology Mutation Organ Size Overexpression Placenta Placenta - cytology Placenta - metabolism Placentation Pregnancy Proteins R&D Research & development RNA, Small Interfering - genetics Studies Thorium Thyroid Thyroid gland Thyroid Hormones - metabolism Triiodothyronine Trophoblasts - metabolism Weight reduction
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