miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer

The epithelial-to-mesenchymal transition (EMT) is a highly conserved physiological program involved in development and tissue repair; however, its aberrant activation has been implicated in accelerating the progression of a variety of cancers. In breast cancer, the microRNAs (miRNAs) miR-221 and miR...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66502-e66502
Hauptverfasser:	Hwang, Michael S, Yu, Nancy, Stinson, Susanna Y, Yue, Peng, Newman, Robert J, Allan, Bernard B, Dornan, David
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions Aberration Activation Adiponectin Apoptosis Biology Biotechnology Blotting, Western Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cell Line, Tumor Comparative analysis Depletion Development and progression Epithelial-Mesenchymal Transition - genetics Epithelial-Mesenchymal Transition - physiology Female Fluorescent Antibody Technique Gene expression Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Humans Insulin resistance Interleukin 6 Kinases Medicine Mesenchyme Metastases Metastasis MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular biology NF-κB protein Pathogenesis Phosphorylation Physiological aspects Real-Time Polymerase Chain Reaction Receptors, Adiponectin - genetics Receptors, Adiponectin - metabolism Rodents siRNA Stat3 protein Stem cells Transcription Transcription factors Tricho-rhino-phalangeal syndrome Tumor cell lines Tumors
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