Vaccination with recombinant Mycobacterium tuberculosis PknD attenuates bacterial dissemination to the brain in guinea pigs

We have previously identified Mycobacterium tuberculosis PknD to be an important virulence factor required for the pathogenesis of central nervous system (CNS) tuberculosis (TB). Specifically, PknD mediates bacillary invasion of the blood-brain barrier, which can be neutralized by specific antisera,...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66310-e66310
Hauptverfasser:	Skerry, Ciaran, Pokkali, Supriya, Pinn, Michael, Be, Nicholas A, Harper, Jamie, Karakousis, Petros C, Jain, Sanjay K
Format:	Artikel
Sprache:	eng
Schlagworte:	aerosols Animals Antigens Antisera Antitubercular agents Bacillus Calmette-Guerin vaccine Bacteria Bacterial Proteins - genetics Bacterial Proteins - immunology Bacterial Proteins - metabolism BASIC BIOLOGICAL SCIENCES BCG BCG Vaccine - therapeutic use Biology Blood-brain barrier Brain - microbiology Brain research Central nervous system Children Comparative analysis Disease Models, Animal Drug dosages Guinea Pigs HIV vaccines Immunization Immunoglobulin G Infections Kinases Medicine Meningitis Mycobacterium bovis Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - metabolism Mycobacterium tuberculosis - pathogenicity Pathogenesis Pediatrics Physicians Proteins recombinant vaccines Sensors Tuberculosis Tuberculosis vaccines Tuberculosis, Central Nervous System - immunology Vaccination vaccination and immunization Virulence Virulence (Microbiology) Virulence factors
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