DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice

G protein-coupled receptor 40 (GPR40) mediates both acute and chronic effects of free fatty acids (FFAs) on insulin secretion. However, it remains controversial whether inhibition of GPR40 would be beneficial in prevention of type 2 diabetes. This study is designed to evaluate the potential effects...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66744-e66744
Hauptverfasser:	Sun, Peng, Wang, Ting, Zhou, Yuren, Liu, Hong, Jiang, Hualiang, Zhu, Weiliang, Wang, Heyao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemical analysis Biology Blood Blood glucose Blood Glucose - drug effects Chronic effects Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - drug therapy Endoplasmic reticulum Experiments Fatty acids Glucose Glucose tolerance Glucose Tolerance Test Homeostasis Hyperglycemia Hyperinsulinemia Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Immunohistochemistry Insulin Insulin resistance Insulin secretion Insulin-Secreting Cells - drug effects Male Medicine Mice Mice, Obese Obesity Pancreas Pharmacology Receptors, G-Protein-Coupled - antagonists & inhibitors Rodents Sensitivity Studies Veins & arteries
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