Genetic associations of type 2 diabetes with islet amyloid polypeptide processing and degrading pathways in asian populations

Type 2 diabetes (T2D) is a complex disease characterized by beta cell dysfunctions. Islet amyloid polypeptide (IAPP) is highly conserved and co-secreted with insulin with over 40% of autopsy cases of T2D showing islet amyloid formation due to IAPP aggregation. Dysregulation in IAPP processing, stabi...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e62378-e62378
Hauptverfasser:	Lam, Vincent Kwok Lim, Ma, Ronald Ching Wan, Lee, Heung Man, Hu, Cheng, Park, Kyong Soo, Furuta, Hiroto, Wang, Ying, Tam, Claudia Ha Ting, Sim, Xueling, Ng, Daniel Peng-Keat, Liu, Jianjun, Wong, Tien-Yin, Tai, E Shyong, Morris, Andrew P, Tang, Nelson Leung Sang, Woo, Jean, Leung, Ping Chung, Kong, Alice Pik Shan, Ozaki, Risa, Jia, Wei Ping, Lee, Hong Kyu, Nanjo, Kishio, Xu, Gang, Ng, Maggie Chor Yin, So, Wing-Yee, Chan, Juliana Chung Ngor
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylin Amyloid Asian Continental Ancestry Group Autopsies Autopsy Beta cells Binding sites Bioinformatics Biology Carboxypeptidase E Carboxypeptidase H - genetics Chromatin Chromosomes Consortia Degradation Deoxyribonucleic acid Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics DNA DNA binding proteins Endocrinology Enzymes Epidemiology Gene expression Genetic aspects Genomes Glucose Hospitals Humans Insulin Insulysin - genetics Internal medicine Interrogation Islet Amyloid Polypeptide - genetics Laboratories Medicine Meta-analysis Metabolic disorders Metabolic syndrome Metabolism Obesity Oligomerization Physiological aspects Polymorphism, Single Nucleotide - genetics Polypeptides Protein interaction Public health Regulatory sequences Risk Science Single nucleotide polymorphisms Single-nucleotide polymorphism Small intestine Toxicity Transcription (Genetics) Transcription factors Type 2 diabetes
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