DAP12 overexpression induces osteopenia and impaired early hematopoiesis

ITAM-bearing transmembrane signaling adaptors such as DAP12 and FcRγ are important players in bone homeostasis, but their precise role and functions are still unknown. It has been shown that osteoclast differentiation results from the integration of the RANK and of the DAP12 and FcRγ signaling pathw...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65297-e65297
Hauptverfasser:	Despars, Geneviève, Pandruvada, Subramanya N M, Anginot, Adrienne, Domenget, Chantal, Jurdic, Pierre, Mazzorana, Marlène
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapters Adaptor proteins Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals B cells Biocompatibility Biology Bone Diseases, Metabolic - genetics Bone Diseases, Metabolic - metabolism Bone marrow Bone turnover Cancellous bone Cell culture Cell Proliferation Cells, Cultured Cortical bone Cytokines DAP12 protein Female Flow Cytometry Gene expression Gene Expression Regulation Hematopoiesis Hematopoiesis - genetics Hematopoiesis - physiology Hemopoiesis Homeostasis Humans Ligands Lymphocytes Lymphocytes B Macrophage colony stimulating factor Medicine Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Transgenic Osteoblasts - cytology Osteoblasts - metabolism Osteoclastogenesis Osteoclasts Osteopenia Osteopetrosis Osteoporosis Phosphatase Reverse Transcriptase Polymerase Chain Reaction Rodents Signaling Spleen Spleen - cytology TRANCE protein Transcription factors
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