Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis
Microscopic colitis (MC) is a disease manifested by diarrhoea and is divided into collagenous and lymphocytic colitis. The aetiology is unknown, but auto-immunity is suggested. Auto-antibodies have been only rarely examined in this entity. The aim of the study was to examine the prevalence of auto-a...
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| Veröffentlicht in: | PloS one 2013-06, Vol.8 (6), p.e66088-e66088 |
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| description | Microscopic colitis (MC) is a disease manifested by diarrhoea and is divided into collagenous and lymphocytic colitis. The aetiology is unknown, but auto-immunity is suggested. Auto-antibodies have been only rarely examined in this entity. The aim of the study was to examine the prevalence of auto-antibodies, and to examine associations between the presence of antibodies and clinical findings.
Women with MC verified by biopsy and younger than 73 years, at any Department of Gastroenterology, in the district of Skåne, between 2002 and 2010 were invited to participate in this study. The patients were asked to complete both a questionnaire describing their medical history and the Gastrointestinal Symptom Rating Scale (GSRS). Blood samples were collected. Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), and antibodies against glutamic acid decarboxylase (anti-GAD), islet antigens-like insulin 2 (anti-IA2), thyroid peroxidase (anti-TPO), and thyrotropin receptor (TRAK) were analysed. Of 240 women identified, 133 were finally included in the study, median age 63 (59-67) years. Apart from the MC diagnosis, 52% also suffered from irritable bowel syndrome, 31% from hypertension and 31% from allergy. The prevalence of ANA (14%), ASCA IgG (13%), and anti-TPO antibodies (14%) for these patients was slightly higher than for the general population, and were found together with other concomitant diseases. Patients had more of all gastrointestinal symptoms compared with norm values, irrespective of antibody expression.
Women with MC have a slightly increased prevalence of some auto-antibodies. These antibodies are not associated with symptoms, but are expressed in patients with concomitant diseases, obscuring the pathophysiology and clinical picture of MC. |
| doi_str_mv | 10.1371/journal.pone.0066088 |
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Women with MC verified by biopsy and younger than 73 years, at any Department of Gastroenterology, in the district of Skåne, between 2002 and 2010 were invited to participate in this study. The patients were asked to complete both a questionnaire describing their medical history and the Gastrointestinal Symptom Rating Scale (GSRS). Blood samples were collected. Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), and antibodies against glutamic acid decarboxylase (anti-GAD), islet antigens-like insulin 2 (anti-IA2), thyroid peroxidase (anti-TPO), and thyrotropin receptor (TRAK) were analysed. Of 240 women identified, 133 were finally included in the study, median age 63 (59-67) years. Apart from the MC diagnosis, 52% also suffered from irritable bowel syndrome, 31% from hypertension and 31% from allergy. The prevalence of ANA (14%), ASCA IgG (13%), and anti-TPO antibodies (14%) for these patients was slightly higher than for the general population, and were found together with other concomitant diseases. Patients had more of all gastrointestinal symptoms compared with norm values, irrespective of antibody expression.
Women with MC have a slightly increased prevalence of some auto-antibodies. These antibodies are not associated with symptoms, but are expressed in patients with concomitant diseases, obscuring the pathophysiology and clinical picture of MC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0066088</identifier><identifier>PMID: 23776613</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Allergies ; Annan klinisk medicin ; Antibodies ; Antibodies, Antineutrophil Cytoplasmic - immunology ; Antibodies, Antinuclear - immunology ; Antibodies, Fungal - immunology ; Antigens ; Antineutrophil cytoplasmic antibodies ; Autoantibodies ; Autoantibodies - immunology ; Biopsy ; Clinical Medicine ; Colitis ; Colitis, Microscopic - immunology ; Collagen ; Diabetes ; Diarrhea ; Female ; Fungi ; Gastroenterologi ; Gastroenterology ; Gastroenterology and Hepatology ; Gastrointestinal symptoms ; Glutamate ; Glutamate decarboxylase ; Glutamic acid ; Health aspects ; Hospitals ; Humans ; Hypersensitivity ; Hypertension ; Immunity ; Immunoglobulin G ; Immunoglobulins ; Inflammatory bowel disease ; Insulin ; Intestine ; Iodide peroxidase ; Iodide Peroxidase - immunology ; Irritable bowel syndrome ; Klinisk medicin ; Laboratories ; Medical and Health Sciences ; Medical research ; Medicin och hälsovetenskap ; Medicine ; Middle Aged ; Other Clinical Medicine ; Patients ; Peroxidase ; Quality of life ; Receptors, Thyrotropin - immunology ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - immunology ; Thyroid ; Thyroid gland ; Thyroid-stimulating hormone ; Women ; Womens health</subject><ispartof>PloS one, 2013-06, Vol.8 (6), p.e66088-e66088</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Roth et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Roth et al 2013 Roth et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c761t-9b9081243d4b5147994ec6215a8b609fb6de259b36a7b5819f67b6b95b23ad1d3</citedby><cites>FETCH-LOGICAL-c761t-9b9081243d4b5147994ec6215a8b609fb6de259b36a7b5819f67b6b95b23ad1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679050/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679050/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23776613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/3913242$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Mittal, Balraj</contributor><creatorcontrib>Roth, Bodil</creatorcontrib><creatorcontrib>Gustafsson, Rita J</creatorcontrib><creatorcontrib>Ohlsson, Bodil</creatorcontrib><title>Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Microscopic colitis (MC) is a disease manifested by diarrhoea and is divided into collagenous and lymphocytic colitis. The aetiology is unknown, but auto-immunity is suggested. Auto-antibodies have been only rarely examined in this entity. The aim of the study was to examine the prevalence of auto-antibodies, and to examine associations between the presence of antibodies and clinical findings.
Women with MC verified by biopsy and younger than 73 years, at any Department of Gastroenterology, in the district of Skåne, between 2002 and 2010 were invited to participate in this study. The patients were asked to complete both a questionnaire describing their medical history and the Gastrointestinal Symptom Rating Scale (GSRS). Blood samples were collected. Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), and antibodies against glutamic acid decarboxylase (anti-GAD), islet antigens-like insulin 2 (anti-IA2), thyroid peroxidase (anti-TPO), and thyrotropin receptor (TRAK) were analysed. Of 240 women identified, 133 were finally included in the study, median age 63 (59-67) years. Apart from the MC diagnosis, 52% also suffered from irritable bowel syndrome, 31% from hypertension and 31% from allergy. The prevalence of ANA (14%), ASCA IgG (13%), and anti-TPO antibodies (14%) for these patients was slightly higher than for the general population, and were found together with other concomitant diseases. Patients had more of all gastrointestinal symptoms compared with norm values, irrespective of antibody expression.
Women with MC have a slightly increased prevalence of some auto-antibodies. These antibodies are not associated with symptoms, but are expressed in patients with concomitant diseases, obscuring the pathophysiology and clinical picture of MC.</description><subject>Age</subject><subject>Aged</subject><subject>Allergies</subject><subject>Annan klinisk medicin</subject><subject>Antibodies</subject><subject>Antibodies, Antineutrophil Cytoplasmic - immunology</subject><subject>Antibodies, Antinuclear - immunology</subject><subject>Antibodies, Fungal - immunology</subject><subject>Antigens</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Autoantibodies</subject><subject>Autoantibodies - immunology</subject><subject>Biopsy</subject><subject>Clinical Medicine</subject><subject>Colitis</subject><subject>Colitis, Microscopic - immunology</subject><subject>Collagen</subject><subject>Diabetes</subject><subject>Diarrhea</subject><subject>Female</subject><subject>Fungi</subject><subject>Gastroenterologi</subject><subject>Gastroenterology</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal symptoms</subject><subject>Glutamate</subject><subject>Glutamate decarboxylase</subject><subject>Glutamic acid</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hypertension</subject><subject>Immunity</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulins</subject><subject>Inflammatory bowel disease</subject><subject>Insulin</subject><subject>Intestine</subject><subject>Iodide peroxidase</subject><subject>Iodide Peroxidase - immunology</subject><subject>Irritable bowel syndrome</subject><subject>Klinisk medicin</subject><subject>Laboratories</subject><subject>Medical and Health Sciences</subject><subject>Medical research</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Other Clinical Medicine</subject><subject>Patients</subject><subject>Peroxidase</subject><subject>Quality of life</subject><subject>Receptors, Thyrotropin - immunology</subject><subject>Saccharomyces cerevisiae</subject><subject>Saccharomyces cerevisiae - immunology</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid-stimulating hormone</subject><subject>Women</subject><subject>Womens health</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTpMmNMCx-DAws-HUb8tU2QyYZm9TVf29mp7tMZS-khIbkOW-S95xTFM8hWELUwHfbMA5euOU-eLMEgBBA6YPiHDJULUgF0MOT-VnxJMYtABhRQh4XZxVqGkIgOi_61ZjCQvhkZdDWxFJ4Xabe2KEUMQZlRbLBl9c29aVy1lslXNlar63vYmnzTtgZX2orOh-i0UdyZ9UQogp7q0oVnE02Pi0etcJF82z6XxTfP374dvl5sbn6tL5cbRaqITAtmGSAwqpGupYY1g1jtVGkglhQSQBrJdGmwkwiIhqJKWQtaSSRDMsKCQ01uiheHnX3LkQ-mRQ5RISQLAdYJtZHQgex5fvB7sTwhwdh-c1CGDouhmSVM1xqKJlWkqKG1KqWTEAmWgoIk6LVtMlam6NWvDb7Uc7U3LjPQ-bBo-GMSdAqUXFdKc1rVGFOMaq4wjl1JicJApjl3k-XH-XOaGV8GoSbqc53vO15F35xRPLTMMgCbyaBIfwcTUx8Z6MyzglvwnhjA2sgrXGd0Vf_oPebNVGdyH5Y34Z8rjqI8lXd0PwMwnCmlvdQ-dMml0Iu0Nbm9VnA21lAZpL5nToxxsjXX7_8P3v1Y86-PmF7I1zqY3DjoYjjHKyP4KFQ42DaO5Mh4If-unWDH_qLT_2Vw16cJugu6Lah0F9gGiCT</recordid><startdate>20130611</startdate><enddate>20130611</enddate><creator>Roth, Bodil</creator><creator>Gustafsson, Rita J</creator><creator>Ohlsson, Bodil</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AGCHP</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><scope>DOA</scope></search><sort><creationdate>20130611</creationdate><title>Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis</title><author>Roth, Bodil ; Gustafsson, Rita J ; Ohlsson, Bodil</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c761t-9b9081243d4b5147994ec6215a8b609fb6de259b36a7b5819f67b6b95b23ad1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Aged</topic><topic>Allergies</topic><topic>Annan klinisk medicin</topic><topic>Antibodies</topic><topic>Antibodies, Antineutrophil Cytoplasmic - immunology</topic><topic>Antibodies, Antinuclear - immunology</topic><topic>Antibodies, Fungal - immunology</topic><topic>Antigens</topic><topic>Antineutrophil cytoplasmic antibodies</topic><topic>Autoantibodies</topic><topic>Autoantibodies - immunology</topic><topic>Biopsy</topic><topic>Clinical Medicine</topic><topic>Colitis</topic><topic>Colitis, Microscopic - immunology</topic><topic>Collagen</topic><topic>Diabetes</topic><topic>Diarrhea</topic><topic>Female</topic><topic>Fungi</topic><topic>Gastroenterologi</topic><topic>Gastroenterology</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastrointestinal symptoms</topic><topic>Glutamate</topic><topic>Glutamate decarboxylase</topic><topic>Glutamic acid</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypersensitivity</topic><topic>Hypertension</topic><topic>Immunity</topic><topic>Immunoglobulin G</topic><topic>Immunoglobulins</topic><topic>Inflammatory bowel disease</topic><topic>Insulin</topic><topic>Intestine</topic><topic>Iodide peroxidase</topic><topic>Iodide Peroxidase - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roth, Bodil</au><au>Gustafsson, Rita J</au><au>Ohlsson, Bodil</au><au>Mittal, Balraj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-06-11</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><spage>e66088</spage><epage>e66088</epage><pages>e66088-e66088</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Microscopic colitis (MC) is a disease manifested by diarrhoea and is divided into collagenous and lymphocytic colitis. The aetiology is unknown, but auto-immunity is suggested. Auto-antibodies have been only rarely examined in this entity. The aim of the study was to examine the prevalence of auto-antibodies, and to examine associations between the presence of antibodies and clinical findings.
Women with MC verified by biopsy and younger than 73 years, at any Department of Gastroenterology, in the district of Skåne, between 2002 and 2010 were invited to participate in this study. The patients were asked to complete both a questionnaire describing their medical history and the Gastrointestinal Symptom Rating Scale (GSRS). Blood samples were collected. Anti-nuclear antibodies (ANA), anti-neutrophil cytoplasmic antibodies (ANCA), anti-Saccharomyces cerevisiae antibodies (ASCA), and antibodies against glutamic acid decarboxylase (anti-GAD), islet antigens-like insulin 2 (anti-IA2), thyroid peroxidase (anti-TPO), and thyrotropin receptor (TRAK) were analysed. Of 240 women identified, 133 were finally included in the study, median age 63 (59-67) years. Apart from the MC diagnosis, 52% also suffered from irritable bowel syndrome, 31% from hypertension and 31% from allergy. The prevalence of ANA (14%), ASCA IgG (13%), and anti-TPO antibodies (14%) for these patients was slightly higher than for the general population, and were found together with other concomitant diseases. Patients had more of all gastrointestinal symptoms compared with norm values, irrespective of antibody expression.
Women with MC have a slightly increased prevalence of some auto-antibodies. These antibodies are not associated with symptoms, but are expressed in patients with concomitant diseases, obscuring the pathophysiology and clinical picture of MC.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23776613</pmid><doi>10.1371/journal.pone.0066088</doi><tpages>e66088</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1366647909 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Allergies Annan klinisk medicin Antibodies Antibodies, Antineutrophil Cytoplasmic - immunology Antibodies, Antinuclear - immunology Antibodies, Fungal - immunology Antigens Antineutrophil cytoplasmic antibodies Autoantibodies Autoantibodies - immunology Biopsy Clinical Medicine Colitis Colitis, Microscopic - immunology Collagen Diabetes Diarrhea Female Fungi Gastroenterologi Gastroenterology Gastroenterology and Hepatology Gastrointestinal symptoms Glutamate Glutamate decarboxylase Glutamic acid Health aspects Hospitals Humans Hypersensitivity Hypertension Immunity Immunoglobulin G Immunoglobulins Inflammatory bowel disease Insulin Intestine Iodide peroxidase Iodide Peroxidase - immunology Irritable bowel syndrome Klinisk medicin Laboratories Medical and Health Sciences Medical research Medicin och hälsovetenskap Medicine Middle Aged Other Clinical Medicine Patients Peroxidase Quality of life Receptors, Thyrotropin - immunology Saccharomyces cerevisiae Saccharomyces cerevisiae - immunology Thyroid Thyroid gland Thyroid-stimulating hormone Women Womens health |
| title | Auto-antibodies and their association with clinical findings in women diagnosed with microscopic colitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-18T21%3A17%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Auto-antibodies%20and%20their%20association%20with%20clinical%20findings%20in%20women%20diagnosed%20with%20microscopic%20colitis&rft.jtitle=PloS%20one&rft.au=Roth,%20Bodil&rft.date=2013-06-11&rft.volume=8&rft.issue=6&rft.spage=e66088&rft.epage=e66088&rft.pages=e66088-e66088&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0066088&rft_dat=%3Cgale_plos_%3EA478325695%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1366647909&rft_id=info:pmid/23776613&rft_galeid=A478325695&rft_doaj_id=oai_doaj_org_article_bd1b9dcb83764c4b9a19af8069bafd87&rfr_iscdi=true |