nfxB as a novel target for analysis of mutation spectra in Pseudomonas aeruginosa

nfxB encodes a negative regulator of the mexCD-oprJ genes for drug efflux in the opportunistic pathogen Pseudomonas aeruginosa. Inactivating mutations in this transcriptional regulator constitute one of the main mechanisms of resistance to ciprofloxacin (Cip(r)). In this work, we evaluated the use o...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66236
Hauptverfasser:	Monti, Mariela R, Morero, Natalia R, Miguel, Virginia, Argaraña, Carlos E
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Aminopurine Amino Acid Sequence Amino Acid Substitution - genetics Amino acids Bacteria Bacterial Proteins - chemistry Bacterial Proteins - genetics Biology Ciprofloxacin Ciprofloxacin - pharmacology Cisplatin Comparative analysis Cystic fibrosis Deoxyribonucleic acid Detection equipment DNA DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics Drug Resistance, Bacterial - drug effects E coli Efflux Escherichia coli Gene mutation Genes Genes, Reporter Genetic aspects Genetic research Hydrogen Hydrogen peroxide Laboratories Luminescence Metabolism Models, Molecular Molecular Sequence Data Mutagenesis Mutagens Mutagens - toxicity Mutants Mutation Mutation - genetics Mutation Rate Opportunist infection Phenols Plasmids Proteins Pseudomonas Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics RNA polymerase Sequence Analysis, DNA Sequences Spectra Transcription Transcription (Genetics) Transcription Factors - chemistry Transcription Factors - genetics
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