Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction
This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP ra...
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| description | This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model. |
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SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0066655</identifier><identifier>PMID: 23762494</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acetylcholine - pharmacology ; Animals ; Antioxidants ; Antioxidants (Nutrients) ; Antioxidants - metabolism ; Aorta ; Aorta - drug effects ; Aorta - metabolism ; Aorta - pathology ; Biology ; Blood pressure ; Blood Pressure - drug effects ; Body Weight - drug effects ; Brassica napus ; Canola ; Canola oil ; Catalase ; Cholesterol ; Chromatography ; Contractility ; CYBB protein ; Diet ; Drinking Behavior - drug effects ; Drinking water ; Endothelium ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiopathology ; Fatty Acids, Monounsaturated - pharmacology ; Feeding Behavior - drug effects ; Gene Expression Regulation - drug effects ; Glutathione ; Glutathione peroxidase ; Hypertension ; In Vitro Techniques ; Ingestion ; Isoforms ; Lipids ; Lipids - blood ; Low density lipoprotein ; Low density lipoproteins ; Malondialdehyde ; Medicine ; mRNA ; NAD(P)H oxidase ; Nitric oxide ; Nitroprusside - pharmacology ; Norepinephrine ; Norepinephrine - pharmacology ; Oils & fats ; Oxidases ; Oxidative stress ; Oxidative Stress - drug effects ; Pathogenesis ; Peroxidase ; Rapeseed Oil ; Rats ; Rats, Inbred SHR ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Rodents ; Salt ; Salt loading ; Salts ; Sodium chloride ; Sodium Chloride - pharmacology ; Soybean oil ; Soybean Oil - pharmacology ; Soybeans ; Stroke ; Stroke - pathology ; Stroke - physiopathology ; Superoxide dismutase ; Superoxides ; Systole - drug effects ; Toxicology ; Triglycerides ; Vegetable oils ; Water</subject><ispartof>PloS one, 2013-06, Vol.8 (6), p.e66655</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Papazzo et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Papazzo et al 2013 Papazzo et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-91efb22db70031bbb625bcc254830ee0724eb2ed4749749319844f23f6e0b6053</citedby><cites>FETCH-LOGICAL-c692t-91efb22db70031bbb625bcc254830ee0724eb2ed4749749319844f23f6e0b6053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676377/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3676377/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23762494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Müller, Michael</contributor><creatorcontrib>Papazzo, Annateresa</creatorcontrib><creatorcontrib>Conlan, Xavier A</creatorcontrib><creatorcontrib>Lexis, Louise</creatorcontrib><creatorcontrib>Charchar, Fadi J</creatorcontrib><creatorcontrib>Lewandowski, Paul A</creatorcontrib><title>Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study aimed to determine if 50 days of canola oil intake in the absence or presence of salt loading affects: (1) antioxidant and oxidative stress markers, (2) aortic mRNA of NADPH oxidase (NOX) subunits and superoxide dismutase (SOD) isoforms and (3) endothelial function in SHRSP rats. SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model.</description><subject>Acetylcholine - pharmacology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants (Nutrients)</subject><subject>Antioxidants - metabolism</subject><subject>Aorta</subject><subject>Aorta - drug effects</subject><subject>Aorta - metabolism</subject><subject>Aorta - pathology</subject><subject>Biology</subject><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Brassica napus</subject><subject>Canola</subject><subject>Canola oil</subject><subject>Catalase</subject><subject>Cholesterol</subject><subject>Chromatography</subject><subject>Contractility</subject><subject>CYBB protein</subject><subject>Diet</subject><subject>Drinking Behavior - drug effects</subject><subject>Drinking water</subject><subject>Endothelium</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiopathology</subject><subject>Fatty Acids, Monounsaturated - pharmacology</subject><subject>Feeding Behavior - drug effects</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Glutathione</subject><subject>Glutathione peroxidase</subject><subject>Hypertension</subject><subject>In Vitro Techniques</subject><subject>Ingestion</subject><subject>Isoforms</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Low density lipoprotein</subject><subject>Low density lipoproteins</subject><subject>Malondialdehyde</subject><subject>Medicine</subject><subject>mRNA</subject><subject>NAD(P)H oxidase</subject><subject>Nitric oxide</subject><subject>Nitroprusside - pharmacology</subject><subject>Norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>Oils & fats</subject><subject>Oxidases</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pathogenesis</subject><subject>Peroxidase</subject><subject>Rapeseed Oil</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Rodents</subject><subject>Salt</subject><subject>Salt loading</subject><subject>Salts</subject><subject>Sodium chloride</subject><subject>Sodium Chloride - pharmacology</subject><subject>Soybean oil</subject><subject>Soybean Oil - pharmacology</subject><subject>Soybeans</subject><subject>Stroke</subject><subject>Stroke - pathology</subject><subject>Stroke - physiopathology</subject><subject>Superoxide dismutase</subject><subject>Superoxides</subject><subject>Systole - drug effects</subject><subject>Toxicology</subject><subject>Triglycerides</subject><subject>Vegetable oils</subject><subject>Water</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNku-LFCEYx4couh_1H0QNBAe92M1RR8c3wXFUt3BwcVu9FUef2XVxddOZ6P773Hbu2IGCUFD083wf_fItilcVmleEV-83YYheufkueJgjxBir6yfFaSUInjGMyNOj_UlxltIGoZo0jD0vTjDhDFNBT4vFUrm-dEEZ61el9aVWPjhVBuvKDky5vL5bfimj6lO-NIOGVII3oV-Ds8qV5j51g9e9Df5F8axTLsHLcT0vvn36-PXqenZz-3lxdXkz00zgfiYq6FqMTcsRIlXbtgzXrda4pg1BAIhjCi0GQzkVeZJKNJR2mHQMUMvyD86LNwfdnQtJji4kWRFWN6iuOc3E4kCYoDZyF-1WxXsZlJV_DkJcSRV7qx1IXEO2hPAGQW7WQMMaJYw2XHCNhTBZ68PYbWi3YDT4Pio3EZ3eeLuWq_BTEsazLs8Cb0eBGH4MkPp_PHmkViq_yvouZDG9tUnLS8obipCoRabmf6HyMLC1Ouegs_l8UvBuUpCZHn71KzWkJBfLu_9nb79P2Ysjdg05Q-sU3LDPQZqC9ADqGFKK0D06VyG5j_GDG3IfYznGOJe9Pnb9seght-Q34XjrSg</recordid><startdate>20130607</startdate><enddate>20130607</enddate><creator>Papazzo, Annateresa</creator><creator>Conlan, Xavier A</creator><creator>Lexis, Louise</creator><creator>Charchar, Fadi J</creator><creator>Lewandowski, Paul A</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130607</creationdate><title>Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction</title><author>Papazzo, Annateresa ; Conlan, Xavier A ; Lexis, Louise ; Charchar, Fadi J ; Lewandowski, Paul A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-91efb22db70031bbb625bcc254830ee0724eb2ed4749749319844f23f6e0b6053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylcholine - pharmacology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants (Nutrients)</topic><topic>Antioxidants - metabolism</topic><topic>Aorta</topic><topic>Aorta - drug effects</topic><topic>Aorta - metabolism</topic><topic>Aorta - pathology</topic><topic>Biology</topic><topic>Blood pressure</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Brassica napus</topic><topic>Canola</topic><topic>Canola oil</topic><topic>Catalase</topic><topic>Cholesterol</topic><topic>Chromatography</topic><topic>Contractility</topic><topic>CYBB protein</topic><topic>Diet</topic><topic>Drinking Behavior - drug effects</topic><topic>Drinking water</topic><topic>Endothelium</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiopathology</topic><topic>Fatty Acids, Monounsaturated - pharmacology</topic><topic>Feeding Behavior - drug effects</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Glutathione</topic><topic>Glutathione peroxidase</topic><topic>Hypertension</topic><topic>In Vitro Techniques</topic><topic>Ingestion</topic><topic>Isoforms</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Low density lipoprotein</topic><topic>Low density lipoproteins</topic><topic>Malondialdehyde</topic><topic>Medicine</topic><topic>mRNA</topic><topic>NAD(P)H oxidase</topic><topic>Nitric oxide</topic><topic>Nitroprusside - pharmacology</topic><topic>Norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>Oils & fats</topic><topic>Oxidases</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pathogenesis</topic><topic>Peroxidase</topic><topic>Rapeseed Oil</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Rodents</topic><topic>Salt</topic><topic>Salt loading</topic><topic>Salts</topic><topic>Sodium chloride</topic><topic>Sodium Chloride - pharmacology</topic><topic>Soybean oil</topic><topic>Soybean Oil - pharmacology</topic><topic>Soybeans</topic><topic>Stroke</topic><topic>Stroke - pathology</topic><topic>Stroke - 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SHRSP rats were fed a diet containing 10 wt/wt% soybean oil or 10 wt/wt% canola oil, and given tap water or water containing 1% NaCl for 50 days. Without salt, canola oil significantly increased RBC SOD, plasma cholesterol and triglycerides, aortic p22 (phox) , NOX2 and CuZn-SOD mRNA, and decreased RBC glutathione peroxidase activity. With salt, canola oil reduced RBC SOD and catalase activity, LDL-C, and p22 (phox) mRNA compared with canola oil alone, whereas plasma malondialdehyde (MDA) was reduced and RBC MDA and LDL-C were higher. With salt, the canola oil group had significantly reduced endothelium-dependent vasodilating responses to ACh and contractile responses to norepinephrine compared with the canola oil group without salt and to the WKY rats. These results indicate that ingestion of canola oil increases O2 (-) generation, and that canola oil ingestion in combination with salt leads to endothelial dysfunction in the SHRSP model.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23762494</pmid><doi>10.1371/journal.pone.0066655</doi><tpages>e66655</tpages><oa>free_for_read</oa></addata></record> |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Acetylcholine - pharmacology Animals Antioxidants Antioxidants (Nutrients) Antioxidants - metabolism Aorta Aorta - drug effects Aorta - metabolism Aorta - pathology Biology Blood pressure Blood Pressure - drug effects Body Weight - drug effects Brassica napus Canola Canola oil Catalase Cholesterol Chromatography Contractility CYBB protein Diet Drinking Behavior - drug effects Drinking water Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiopathology Fatty Acids, Monounsaturated - pharmacology Feeding Behavior - drug effects Gene Expression Regulation - drug effects Glutathione Glutathione peroxidase Hypertension In Vitro Techniques Ingestion Isoforms Lipids Lipids - blood Low density lipoprotein Low density lipoproteins Malondialdehyde Medicine mRNA NAD(P)H oxidase Nitric oxide Nitroprusside - pharmacology Norepinephrine Norepinephrine - pharmacology Oils & fats Oxidases Oxidative stress Oxidative Stress - drug effects Pathogenesis Peroxidase Rapeseed Oil Rats Rats, Inbred SHR RNA RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Salt Salt loading Salts Sodium chloride Sodium Chloride - pharmacology Soybean oil Soybean Oil - pharmacology Soybeans Stroke Stroke - pathology Stroke - physiopathology Superoxide dismutase Superoxides Systole - drug effects Toxicology Triglycerides Vegetable oils Water |
| title | Salt loading in canola oil fed SHRSP rats induces endothelial dysfunction |
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