The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells

In mice, successful development and reproduction require that all cells, including germ cells, transition from a pluripotent to a differentiated state. This transition is associated with silencing of the pluripotency genes Oct4 and Nanog. Interestingly, these genes are repressed at different develop...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e66062
Hauptverfasser:	Okumura, Leah M, Lesch, Bluma J, Page, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Biology Cellular biology Down-Regulation Embryo cells Embryonic development Embryonic stem cells Exons - genetics Female Fetus - cytology Fetuses Gastrulation GCNF gene Gene expression Gene Expression Regulation, Developmental Gene regulation Gene silencing Gene Targeting Genes Genetic aspects Germ cells Germ Cells - cytology Germ Cells - metabolism Homeodomain Proteins - metabolism House mouse Hybridization Ligands Meiosis Mice Mice, Inbred C57BL Mice, Mutant Strains Mutation - genetics Nanog Homeobox Protein Nuclear Receptor Subfamily 6, Group A, Member 1 - chemistry Nuclear Receptor Subfamily 6, Group A, Member 1 - metabolism Oct-4 protein Octamer Transcription Factor-3 - metabolism Oogenesis Ovary - cytology Ovary - embryology Ovary - metabolism Phenotype Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Protein Binding Protein Structure, Tertiary Proteins Rodents Sequence Deletion Silence Somatic cells Stem cell transplantation Stem cells Structure-Activity Relationship Tamoxifen
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