Association of eosinophilic inflammation with FKBP51 expression in sputum cells in asthma

Airway eosinophilia is a predictor of steroid responsiveness in steroid-naïve asthma. However, the relationship between airway eosinophilia and the expression of FK506-binding protein 51 (FKBP51), a glucocorticoid receptor co-chaperone that plays a role in steroid insensitivity in asthma, remains un...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65284
Hauptverfasser:	Tajiri, Tomoko, Matsumoto, Hisako, Niimi, Akio, Ito, Isao, Oguma, Tsuyoshi, Nakaji, Hitoshi, Inoue, Hideki, Iwata, Toshiyuki, Nagasaki, Tadao, Kanemitsu, Yoshihiro, Petrova, Guergana, Mishima, Michiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Cortex Hormones - therapeutic use Adult Aged Aged, 80 and over Apoptosis Asthma Asthma - drug therapy Asthma - genetics Asthma - immunology Asthma - pathology Biology Blood Blood diseases Corticosteroids Cross-Sectional Studies Eosinophilia Eosinophils - immunology Eosinophils - pathology Exhalation Female Forced Expiratory Volume Gene Expression Glucocorticoids Humans Inflammation Kinases Leukocyte Count Leukocytes (eosinophilic) Male Mathematics Medicine Middle Aged mRNA Nitric oxide Nitric Oxide - metabolism Patients Protein binding Proteins Real-Time Polymerase Chain Reaction Respiratory tract RNA Severity of Illness Index Sputum Sputum - cytology Tacrolimus Tacrolimus Binding Proteins - genetics Tacrolimus Binding Proteins - immunology Tacrolimus-binding protein
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