Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes
High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major...
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| Veröffentlicht in: | PloS one 2013-06, Vol.8 (6), p.e64729-e64729 |
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| creator | Menzaghi, Claudia Bacci, Simonetta Salvemini, Lucia Mendonca, Christine Palladino, Giuseppe Fontana, Andrea De Bonis, Concetta Marucci, Antonella Goheen, Elizabeth Prudente, Sabrina Morini, Eleonora Rizza, Stefano Kanagaki, Alyssa Fini, Grazia Mangiacotti, Davide Federici, Massimo De Cosmo, Salvatore Pellegrini, Fabio Doria, Alessandro Trischitta, Vincenzo |
| description | High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes.
We tested the association of circulating resistin concentrations with coronary artery disease, major cardiovascular events (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and all-cause mortality in 2,313 diabetic patients of European ancestry from two cross-sectional and two prospective studies. In addition, the expression of resistin gene (RETN) was measured in blood cells of 68 diabetic patients and correlated with their serum resistin levels.
In a model comprising age, sex, smoking habits, BMI, HbA1c, and insulin, antihypertensive and antidyslipidemic therapies, serum resistin was associated with coronary artery disease in both cross-sectional studies: OR (95%CI) per SD increment = 1.35 (1.10-1.64) and 1.99 (1.55-2.55). Additionally, serum resistin predicted incident major cardiovascular events (HR per SD increment = 1.31; 1.10-1.56) and all-cause mortality (HR per SD increment = 1.16; 1.06-1.26). Adjusting also for fibrinogen levels affected the association with coronary artery disease and incident cardiovascular events, but not that with all cause-mortality. Finally, serum resistin was positively correlated with RETN mRNA expression (rho = 0.343).
This is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry. |
| doi_str_mv | 10.1371/journal.pone.0064729 |
| format | Article |
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We tested the association of circulating resistin concentrations with coronary artery disease, major cardiovascular events (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and all-cause mortality in 2,313 diabetic patients of European ancestry from two cross-sectional and two prospective studies. In addition, the expression of resistin gene (RETN) was measured in blood cells of 68 diabetic patients and correlated with their serum resistin levels.
In a model comprising age, sex, smoking habits, BMI, HbA1c, and insulin, antihypertensive and antidyslipidemic therapies, serum resistin was associated with coronary artery disease in both cross-sectional studies: OR (95%CI) per SD increment = 1.35 (1.10-1.64) and 1.99 (1.55-2.55). Additionally, serum resistin predicted incident major cardiovascular events (HR per SD increment = 1.31; 1.10-1.56) and all-cause mortality (HR per SD increment = 1.16; 1.06-1.26). Adjusting also for fibrinogen levels affected the association with coronary artery disease and incident cardiovascular events, but not that with all cause-mortality. Finally, serum resistin was positively correlated with RETN mRNA expression (rho = 0.343).
This is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0064729</identifier><identifier>PMID: 23755138</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Angina pectoris ; Antihypertensives ; Biology ; Blood cells ; Body mass ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - mortality ; Case-Control Studies ; Cerebral infarction ; Complications and side effects ; Confidence Intervals ; Coronary artery ; Coronary artery disease ; Coronary vessels ; Cross-Sectional Studies ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - mortality ; Disease control ; Endocrinology ; Female ; Fibrinogen ; Gene expression ; Gene Expression Regulation ; Genetic aspects ; Glucose ; Habits ; Health risk assessment ; Health risks ; Heart attacks ; Heart diseases ; Hemoglobin ; Humans ; Insulin ; Internal medicine ; Ischemia ; Laboratories ; Male ; Medical imaging ; Medical prognosis ; Medicine ; Middle Aged ; Mortality ; Myocardial infarction ; Odds Ratio ; Patients ; Peptide hormones ; Physiological aspects ; Prospective Studies ; Resistin - blood ; Resistin - genetics ; Risk factors ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Smoking ; Stroke ; Studies ; Survival Analysis ; Type 2 diabetes</subject><ispartof>PloS one, 2013-06, Vol.8 (6), p.e64729-e64729</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Menzaghi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Menzaghi et al 2013 Menzaghi et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-88f7d5fa8692ce7ee3732ecbd8082f00e032febc4a085da60453a9c5777e8cc43</citedby><cites>FETCH-LOGICAL-c692t-88f7d5fa8692ce7ee3732ecbd8082f00e032febc4a085da60453a9c5777e8cc43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670852/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670852/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23755138$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Menzaghi, Claudia</creatorcontrib><creatorcontrib>Bacci, Simonetta</creatorcontrib><creatorcontrib>Salvemini, Lucia</creatorcontrib><creatorcontrib>Mendonca, Christine</creatorcontrib><creatorcontrib>Palladino, Giuseppe</creatorcontrib><creatorcontrib>Fontana, Andrea</creatorcontrib><creatorcontrib>De Bonis, Concetta</creatorcontrib><creatorcontrib>Marucci, Antonella</creatorcontrib><creatorcontrib>Goheen, Elizabeth</creatorcontrib><creatorcontrib>Prudente, Sabrina</creatorcontrib><creatorcontrib>Morini, Eleonora</creatorcontrib><creatorcontrib>Rizza, Stefano</creatorcontrib><creatorcontrib>Kanagaki, Alyssa</creatorcontrib><creatorcontrib>Fini, Grazia</creatorcontrib><creatorcontrib>Mangiacotti, Davide</creatorcontrib><creatorcontrib>Federici, Massimo</creatorcontrib><creatorcontrib>De Cosmo, Salvatore</creatorcontrib><creatorcontrib>Pellegrini, Fabio</creatorcontrib><creatorcontrib>Doria, Alessandro</creatorcontrib><creatorcontrib>Trischitta, Vincenzo</creatorcontrib><title>Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes.
We tested the association of circulating resistin concentrations with coronary artery disease, major cardiovascular events (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and all-cause mortality in 2,313 diabetic patients of European ancestry from two cross-sectional and two prospective studies. In addition, the expression of resistin gene (RETN) was measured in blood cells of 68 diabetic patients and correlated with their serum resistin levels.
In a model comprising age, sex, smoking habits, BMI, HbA1c, and insulin, antihypertensive and antidyslipidemic therapies, serum resistin was associated with coronary artery disease in both cross-sectional studies: OR (95%CI) per SD increment = 1.35 (1.10-1.64) and 1.99 (1.55-2.55). Additionally, serum resistin predicted incident major cardiovascular events (HR per SD increment = 1.31; 1.10-1.56) and all-cause mortality (HR per SD increment = 1.16; 1.06-1.26). Adjusting also for fibrinogen levels affected the association with coronary artery disease and incident cardiovascular events, but not that with all cause-mortality. Finally, serum resistin was positively correlated with RETN mRNA expression (rho = 0.343).
This is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry.</description><subject>Angina pectoris</subject><subject>Antihypertensives</subject><subject>Biology</subject><subject>Blood cells</subject><subject>Body mass</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Case-Control Studies</subject><subject>Cerebral infarction</subject><subject>Complications and side effects</subject><subject>Confidence Intervals</subject><subject>Coronary artery</subject><subject>Coronary artery disease</subject><subject>Coronary vessels</subject><subject>Cross-Sectional Studies</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - mortality</subject><subject>Disease control</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fibrinogen</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Genetic aspects</subject><subject>Glucose</subject><subject>Habits</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Heart attacks</subject><subject>Heart diseases</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal medicine</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Myocardial infarction</subject><subject>Odds Ratio</subject><subject>Patients</subject><subject>Peptide hormones</subject><subject>Physiological aspects</subject><subject>Prospective Studies</subject><subject>Resistin - blood</subject><subject>Resistin - genetics</subject><subject>Risk factors</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Smoking</subject><subject>Stroke</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk29v0zAQxiMEYmPwDRBEQkIg0eLYie28QZom_lSaNIkBb62Lc2k9uXFnO4N-e9w1mxq0FygvYju_5znf5S7LXhZkXjBRfLxyg-_BzjeuxzkhvBS0fpQdFzWjM04Je3ywPsqehXBFSMUk50-zI8pEVRVMHmfqEv2wzj0GE6LpP-QafGvcDQQ9WPB5awJCwBz6NgdrZxqGtFs7H8GauM1Nn28gGuxjyH-buMrjdoM5TTpoMGJ4nj3pwAZ8Mb5Psp9fPv84-zY7v_i6ODs9n2le0ziTshNt1YFMO40CkQlGUTetJJJ2hCBhtMNGl0Bk1QInZcWg1pUQAqXWJTvJXu99N9YFNdYmqIJxRrnkVZWIxZ5oHVypjTdr8FvlwKjbA-eXCnw02qKCtqtqwSue4pZM0kY0skyruiUsRWyS16cx2tCssdUpfQ92Yjr90puVWrobxbhICdBk8G408O56wBDV2gSN1kKPbri9N5eUSs4S-uYf9OHsRmoJKQHTdy7F1TtTdVoKWTJOWZGo-QNUelpcG50aqTPpfCJ4PxEkJuKfuExdENTi8vv_sxe_puzbA3aFYOMqODtE4_owBcs9qL0LwWN3X-SCqN0c3FVD7eZAjXOQZK8Of9C96K7x2V_sNAJs</recordid><startdate>20130603</startdate><enddate>20130603</enddate><creator>Menzaghi, Claudia</creator><creator>Bacci, Simonetta</creator><creator>Salvemini, Lucia</creator><creator>Mendonca, Christine</creator><creator>Palladino, Giuseppe</creator><creator>Fontana, Andrea</creator><creator>De Bonis, Concetta</creator><creator>Marucci, Antonella</creator><creator>Goheen, Elizabeth</creator><creator>Prudente, Sabrina</creator><creator>Morini, Eleonora</creator><creator>Rizza, Stefano</creator><creator>Kanagaki, Alyssa</creator><creator>Fini, Grazia</creator><creator>Mangiacotti, Davide</creator><creator>Federici, Massimo</creator><creator>De Cosmo, Salvatore</creator><creator>Pellegrini, Fabio</creator><creator>Doria, Alessandro</creator><creator>Trischitta, Vincenzo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130603</creationdate><title>Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes</title><author>Menzaghi, Claudia ; Bacci, Simonetta ; Salvemini, Lucia ; Mendonca, Christine ; Palladino, Giuseppe ; Fontana, Andrea ; De Bonis, Concetta ; Marucci, Antonella ; Goheen, Elizabeth ; Prudente, Sabrina ; Morini, Eleonora ; Rizza, Stefano ; Kanagaki, Alyssa ; Fini, Grazia ; Mangiacotti, Davide ; Federici, Massimo ; De Cosmo, Salvatore ; Pellegrini, Fabio ; Doria, Alessandro ; Trischitta, Vincenzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-88f7d5fa8692ce7ee3732ecbd8082f00e032febc4a085da60453a9c5777e8cc43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Angina pectoris</topic><topic>Antihypertensives</topic><topic>Biology</topic><topic>Blood cells</topic><topic>Body mass</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - 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blood</topic><topic>Resistin - genetics</topic><topic>Risk factors</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Smoking</topic><topic>Stroke</topic><topic>Studies</topic><topic>Survival Analysis</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menzaghi, Claudia</creatorcontrib><creatorcontrib>Bacci, Simonetta</creatorcontrib><creatorcontrib>Salvemini, Lucia</creatorcontrib><creatorcontrib>Mendonca, Christine</creatorcontrib><creatorcontrib>Palladino, Giuseppe</creatorcontrib><creatorcontrib>Fontana, Andrea</creatorcontrib><creatorcontrib>De Bonis, Concetta</creatorcontrib><creatorcontrib>Marucci, Antonella</creatorcontrib><creatorcontrib>Goheen, Elizabeth</creatorcontrib><creatorcontrib>Prudente, Sabrina</creatorcontrib><creatorcontrib>Morini, Eleonora</creatorcontrib><creatorcontrib>Rizza, Stefano</creatorcontrib><creatorcontrib>Kanagaki, Alyssa</creatorcontrib><creatorcontrib>Fini, Grazia</creatorcontrib><creatorcontrib>Mangiacotti, Davide</creatorcontrib><creatorcontrib>Federici, Massimo</creatorcontrib><creatorcontrib>De Cosmo, Salvatore</creatorcontrib><creatorcontrib>Pellegrini, Fabio</creatorcontrib><creatorcontrib>Doria, Alessandro</creatorcontrib><creatorcontrib>Trischitta, Vincenzo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menzaghi, Claudia</au><au>Bacci, Simonetta</au><au>Salvemini, Lucia</au><au>Mendonca, Christine</au><au>Palladino, Giuseppe</au><au>Fontana, Andrea</au><au>De Bonis, Concetta</au><au>Marucci, Antonella</au><au>Goheen, Elizabeth</au><au>Prudente, Sabrina</au><au>Morini, Eleonora</au><au>Rizza, Stefano</au><au>Kanagaki, Alyssa</au><au>Fini, Grazia</au><au>Mangiacotti, Davide</au><au>Federici, Massimo</au><au>De Cosmo, Salvatore</au><au>Pellegrini, Fabio</au><au>Doria, Alessandro</au><au>Trischitta, Vincenzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-06-03</date><risdate>2013</risdate><volume>8</volume><issue>6</issue><spage>e64729</spage><epage>e64729</epage><pages>e64729-e64729</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>High serum resistin has been associated with increased risk of cardiovascular disease in the general population, Only sparse and conflicting results, limited to Asian individuals, have been reported, so far, in type 2 diabetes. We studied the role of serum resistin on coronary artery disease, major cardiovascular events and all-cause mortality in type 2 diabetes.
We tested the association of circulating resistin concentrations with coronary artery disease, major cardiovascular events (cardiovascular death, non-fatal myocardial infarction and non-fatal stroke) and all-cause mortality in 2,313 diabetic patients of European ancestry from two cross-sectional and two prospective studies. In addition, the expression of resistin gene (RETN) was measured in blood cells of 68 diabetic patients and correlated with their serum resistin levels.
In a model comprising age, sex, smoking habits, BMI, HbA1c, and insulin, antihypertensive and antidyslipidemic therapies, serum resistin was associated with coronary artery disease in both cross-sectional studies: OR (95%CI) per SD increment = 1.35 (1.10-1.64) and 1.99 (1.55-2.55). Additionally, serum resistin predicted incident major cardiovascular events (HR per SD increment = 1.31; 1.10-1.56) and all-cause mortality (HR per SD increment = 1.16; 1.06-1.26). Adjusting also for fibrinogen levels affected the association with coronary artery disease and incident cardiovascular events, but not that with all cause-mortality. Finally, serum resistin was positively correlated with RETN mRNA expression (rho = 0.343).
This is the first study showing that high serum resistin (a likely consequence, at least partly, of increased RETN expression) is a risk factor for cardiovascular disease and all-cause mortality in diabetic patients of European ancestry.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23755138</pmid><doi>10.1371/journal.pone.0064729</doi><tpages>e64729</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-06, Vol.8 (6), p.e64729-e64729 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1363268655 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Angina pectoris Antihypertensives Biology Blood cells Body mass Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - complications Cardiovascular Diseases - mortality Case-Control Studies Cerebral infarction Complications and side effects Confidence Intervals Coronary artery Coronary artery disease Coronary vessels Cross-Sectional Studies Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - mortality Disease control Endocrinology Female Fibrinogen Gene expression Gene Expression Regulation Genetic aspects Glucose Habits Health risk assessment Health risks Heart attacks Heart diseases Hemoglobin Humans Insulin Internal medicine Ischemia Laboratories Male Medical imaging Medical prognosis Medicine Middle Aged Mortality Myocardial infarction Odds Ratio Patients Peptide hormones Physiological aspects Prospective Studies Resistin - blood Resistin - genetics Risk factors RNA, Messenger - genetics RNA, Messenger - metabolism Smoking Stroke Studies Survival Analysis Type 2 diabetes |
| title | Serum resistin, cardiovascular disease and all-cause mortality in patients with type 2 diabetes |
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