Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice

Diabetic patients have a much more widespread and aggressive form of atherosclerosis and therefore, higher risk for myocardial infarction, peripheral vascular disease and stroke, but the molecular mechanisms leading to accelerated damage are still unclear. Recently, we showed that hyperglycemia acti...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65020
Hauptverfasser:	Zetterqvist, Anna V, Berglund, Lisa M, Blanco, Fabiana, Garcia-Vaz, Eliana, Wigren, Maria, Dunér, Pontus, Andersson, Anna-Maria Dutius, To, Fong, Spegel, Peter, Nilsson, Jan, Bengtsson, Eva, Gomez, Maria F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Apolipoprotein E Apolipoproteins Apolipoproteins E - deficiency Apolipoproteins E - metabolism Arteriosclerosis Atherogenesis Atherosclerosis Atherosclerosis - blood Atherosclerosis - complications Atherosclerosis - pathology Biocompatibility Biology Biomarkers - metabolism Biomedical materials Blood Glucose - metabolism Body Weight - drug effects Brain Cardiac and Cardiovascular Systems Cardiovascular system Care and treatment Cell activation Cell adhesion Cerebral infarction Cholesterol Cholesterol - blood Clinical Medicine Complications Cytokines Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - complications Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Disease Progression Endocrinology and Diabetes Endokrinologi och diabetes Gene expression Genetic aspects Health risks Heart Hyperglycemia Immunosuppression Immunotherapy Inflammation Inflammation - pathology Inhibition Intercellular adhesion molecule 1 Interleukin 6 Interleukin-6 - blood Kardiologi Kidneys Kinases Klinisk medicin Laboratory animals Liver Medical and Health Sciences Medicin och hälsovetenskap Medicine Mice Mice, Inbred C57BL Molecular modelling Monocyte chemoattractant protein 1 Monocytes - metabolism Myocardial infarction NFATC Transcription Factors - antagonists & inhibitors NFATC Transcription Factors - metabolism Organs Physiological aspects Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology Pyrazoles - pharmacokinetics Pyrazoles - pharmacology Rodents Signal Transduction - drug effects Signaling Smooth muscle Spleen T cells Thymus Transcription factors Transcription, Genetic - drug effects Triglycerides Vascular diseases
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