Cupric ions induce the oxidation and trigger the aggregation of human superoxide dismutase 1

Amyotrophic lateral sclerosis (ALS), partly caused by the mutations and aggregation of human copper, zinc superoxide dismutase (SOD1), is a fatal degenerative disease of motor neurons. Because SOD1 is a major copper-binding protein present at relatively high concentration in motor neurons and copper...

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Veröffentlicht in:	PloS one 2013-06, Vol.8 (6), p.e65287
Hauptverfasser:	Li, Cheng, Xu, Wen-Chang, Xie, Zhen-Sheng, Pan, Kai, Hu, Jiao, Chen, Jie, Pang, Dai-Wen, Yang, Fu-Quan, Liang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Affinity Agglomeration Amino Acid Sequence Amyotrophic lateral sclerosis Atomic force microscopy Binding sites Biochemistry Biology Biophysics Calorimetry Cations, Divalent Chromatography Copper Copper - chemistry Cupric ions Development and progression Disease Escherichia coli - genetics Escherichia coli - metabolism Gel electrophoresis Gene Expression Genetic aspects Homeostasis Humans Hydrogen Hydrogen peroxide Hydrogen Peroxide - chemistry Ions Kinetics Laboratories Life sciences Light scattering Mass spectrometry Mass spectroscopy Medicine Microscopy Molecular Sequence Data Motor neurons Mutants Mutation Neurons Oligomerization Oxidation Oxidation-Reduction Pathogenesis Photon correlation spectroscopy Physiological aspects Protein Aggregates Proteomics Recombinant Proteins - chemistry Recombinant Proteins - genetics Rodents Sodium lauryl sulfate Solutions Superoxide dismutase Superoxide Dismutase - chemistry Superoxide Dismutase - genetics Superoxide Dismutase-1 Thermodynamics Titration Titration calorimetry Transgenic animals Virology Zinc
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