Cognitive decline in older persons initiating anticholinergic medications
This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons. Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e64111 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | e64111 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Shah, Raj C Janos, Alicia L Kline, Julia E Yu, Lei Leurgans, Sue E Wilson, Robert S Wei, Peter Bennett, David A Heilman, Kenneth M Tsao, Jack W |
| description | This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.
Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.
Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p |
| doi_str_mv | 10.1371/journal.pone.0064111 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1362092516</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e4b2c05a77fc445485c26e8a1b5d00ae</doaj_id><sourcerecordid>2986065991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-9ca31d03cbf9f79ae479f91f3346bc038f19aa022fe1088cd2ba83646ca95cfb3</originalsourceid><addsrcrecordid>eNp1UU1r3DAQFaUl3_-gNIaed6Mvy9YlUJYmWQj00pzFWB45WhxpK3kD_ffVZp2QHHqSmHnz5r15hHxldMlEw642cZcCjMttDLikVEnG2CdywrTgC8Wp-Pzuf0xOc95QWotWqSNyzEUjmaDihKxXcQh-8s9Y9WhHH7DyoYpjj6naYsox5FIoAJh8GCoIk7ePcY9Lg7fVE_bellaBnZMvDsaMF_N7Rh5ufv5e3S3uf92uVz_uF7bmalpoC4L1VNjOaddoQNlop5kTQqrOUtE6pgEo5w4ZbVvb8w5aoaSyoGvrOnFGLg-82zFmM18hGyaKUc1rpgpifUD0ETZmm_wTpL8mgjcvhZgGA6n4GNGg7LilNTSNs1LWsq0tV9gC6-qeUsDCdT1v23XFrMUwJRg_kH7sBP9ohvhshFK6SCoE32eCFP_sME__kSwPKJtizgnd2wZGzT7u1ymzj9vMcZexb-_VvQ295iv-AQnjqnM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1362092516</pqid></control><display><type>article</type><title>Cognitive decline in older persons initiating anticholinergic medications</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Public Library of Science (PLoS)</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Shah, Raj C ; Janos, Alicia L ; Kline, Julia E ; Yu, Lei ; Leurgans, Sue E ; Wilson, Robert S ; Wei, Peter ; Bennett, David A ; Heilman, Kenneth M ; Tsao, Jack W</creator><contributor>Forloni, Gianluigi</contributor><creatorcontrib>Shah, Raj C ; Janos, Alicia L ; Kline, Julia E ; Yu, Lei ; Leurgans, Sue E ; Wilson, Robert S ; Wei, Peter ; Bennett, David A ; Heilman, Kenneth M ; Tsao, Jack W ; Forloni, Gianluigi</creatorcontrib><description>This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.
Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.
Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p = 0.1).
Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0064111</identifier><identifier>PMID: 23741303</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Alzheimer's disease ; Anticholinergics ; Catholicism ; Cholinergic Antagonists - adverse effects ; Clergy ; Cognition - drug effects ; Cognition Disorders - drug therapy ; Cognition Disorders - physiopathology ; Cognition Disorders - psychology ; Cognitive ability ; Dementia ; Dementia disorders ; Drug Administration Schedule ; Drugs ; Family medical history ; Female ; Gene amplification ; Health sciences ; Humans ; Language Tests ; Male ; Medicine ; Memory ; Neurology ; Older people ; Psychological Tests ; Religion ; Religious orders ; Risk Factors ; Severity of Illness Index</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e64111</ispartof><rights>2013. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-9ca31d03cbf9f79ae479f91f3346bc038f19aa022fe1088cd2ba83646ca95cfb3</citedby><cites>FETCH-LOGICAL-c526t-9ca31d03cbf9f79ae479f91f3346bc038f19aa022fe1088cd2ba83646ca95cfb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669362/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669362/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23865,27923,27924,53790,53792,79371,79372</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23741303$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Forloni, Gianluigi</contributor><creatorcontrib>Shah, Raj C</creatorcontrib><creatorcontrib>Janos, Alicia L</creatorcontrib><creatorcontrib>Kline, Julia E</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><creatorcontrib>Leurgans, Sue E</creatorcontrib><creatorcontrib>Wilson, Robert S</creatorcontrib><creatorcontrib>Wei, Peter</creatorcontrib><creatorcontrib>Bennett, David A</creatorcontrib><creatorcontrib>Heilman, Kenneth M</creatorcontrib><creatorcontrib>Tsao, Jack W</creatorcontrib><title>Cognitive decline in older persons initiating anticholinergic medications</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.
Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.
Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p = 0.1).
Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Anticholinergics</subject><subject>Catholicism</subject><subject>Cholinergic Antagonists - adverse effects</subject><subject>Clergy</subject><subject>Cognition - drug effects</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognition Disorders - psychology</subject><subject>Cognitive ability</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Drug Administration Schedule</subject><subject>Drugs</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gene amplification</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Language Tests</subject><subject>Male</subject><subject>Medicine</subject><subject>Memory</subject><subject>Neurology</subject><subject>Older people</subject><subject>Psychological Tests</subject><subject>Religion</subject><subject>Religious orders</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp1UU1r3DAQFaUl3_-gNIaed6Mvy9YlUJYmWQj00pzFWB45WhxpK3kD_ffVZp2QHHqSmHnz5r15hHxldMlEw642cZcCjMttDLikVEnG2CdywrTgC8Wp-Pzuf0xOc95QWotWqSNyzEUjmaDihKxXcQh-8s9Y9WhHH7DyoYpjj6naYsox5FIoAJh8GCoIk7ePcY9Lg7fVE_bellaBnZMvDsaMF_N7Rh5ufv5e3S3uf92uVz_uF7bmalpoC4L1VNjOaddoQNlop5kTQqrOUtE6pgEo5w4ZbVvb8w5aoaSyoGvrOnFGLg-82zFmM18hGyaKUc1rpgpifUD0ETZmm_wTpL8mgjcvhZgGA6n4GNGg7LilNTSNs1LWsq0tV9gC6-qeUsDCdT1v23XFrMUwJRg_kH7sBP9ohvhshFK6SCoE32eCFP_sME__kSwPKJtizgnd2wZGzT7u1ymzj9vMcZexb-_VvQ295iv-AQnjqnM</recordid><startdate>20130531</startdate><enddate>20130531</enddate><creator>Shah, Raj C</creator><creator>Janos, Alicia L</creator><creator>Kline, Julia E</creator><creator>Yu, Lei</creator><creator>Leurgans, Sue E</creator><creator>Wilson, Robert S</creator><creator>Wei, Peter</creator><creator>Bennett, David A</creator><creator>Heilman, Kenneth M</creator><creator>Tsao, Jack W</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130531</creationdate><title>Cognitive decline in older persons initiating anticholinergic medications</title><author>Shah, Raj C ; Janos, Alicia L ; Kline, Julia E ; Yu, Lei ; Leurgans, Sue E ; Wilson, Robert S ; Wei, Peter ; Bennett, David A ; Heilman, Kenneth M ; Tsao, Jack W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-9ca31d03cbf9f79ae479f91f3346bc038f19aa022fe1088cd2ba83646ca95cfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Anticholinergics</topic><topic>Catholicism</topic><topic>Cholinergic Antagonists - adverse effects</topic><topic>Clergy</topic><topic>Cognition - drug effects</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognition Disorders - psychology</topic><topic>Cognitive ability</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Drug Administration Schedule</topic><topic>Drugs</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gene amplification</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Language Tests</topic><topic>Male</topic><topic>Medicine</topic><topic>Memory</topic><topic>Neurology</topic><topic>Older people</topic><topic>Psychological Tests</topic><topic>Religion</topic><topic>Religious orders</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shah, Raj C</creatorcontrib><creatorcontrib>Janos, Alicia L</creatorcontrib><creatorcontrib>Kline, Julia E</creatorcontrib><creatorcontrib>Yu, Lei</creatorcontrib><creatorcontrib>Leurgans, Sue E</creatorcontrib><creatorcontrib>Wilson, Robert S</creatorcontrib><creatorcontrib>Wei, Peter</creatorcontrib><creatorcontrib>Bennett, David A</creatorcontrib><creatorcontrib>Heilman, Kenneth M</creatorcontrib><creatorcontrib>Tsao, Jack W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shah, Raj C</au><au>Janos, Alicia L</au><au>Kline, Julia E</au><au>Yu, Lei</au><au>Leurgans, Sue E</au><au>Wilson, Robert S</au><au>Wei, Peter</au><au>Bennett, David A</au><au>Heilman, Kenneth M</au><au>Tsao, Jack W</au><au>Forloni, Gianluigi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cognitive decline in older persons initiating anticholinergic medications</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-31</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e64111</spage><pages>e64111-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.
Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.
Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p = 0.1).
Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23741303</pmid><doi>10.1371/journal.pone.0064111</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5), p.e64111 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1362092516 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Aged Aged, 80 and over Aging Alzheimer's disease Anticholinergics Catholicism Cholinergic Antagonists - adverse effects Clergy Cognition - drug effects Cognition Disorders - drug therapy Cognition Disorders - physiopathology Cognition Disorders - psychology Cognitive ability Dementia Dementia disorders Drug Administration Schedule Drugs Family medical history Female Gene amplification Health sciences Humans Language Tests Male Medicine Memory Neurology Older people Psychological Tests Religion Religious orders Risk Factors Severity of Illness Index |
| title | Cognitive decline in older persons initiating anticholinergic medications |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T19%3A59%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cognitive%20decline%20in%20older%20persons%20initiating%20anticholinergic%20medications&rft.jtitle=PloS%20one&rft.au=Shah,%20Raj%20C&rft.date=2013-05-31&rft.volume=8&rft.issue=5&rft.spage=e64111&rft.pages=e64111-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0064111&rft_dat=%3Cproquest_plos_%3E2986065991%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1362092516&rft_id=info:pmid/23741303&rft_doaj_id=oai_doaj_org_article_e4b2c05a77fc445485c26e8a1b5d00ae&rfr_iscdi=true |