Transforming growth factor-beta inhibition reduces progression of early choroidal neovascularization lesions in rats: P17 and P144 peptides

The purpose of this study was to assess the effects of transforming growth factor beta (TGF-β) inhibitor peptides (P17 & P144) on early laser-induced choroidal neovascularization (LI-CNV) lesions in rats, two weeks after laser CNV induction. Seventy-one Long Evans rats underwent diode laser appl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e65434
Hauptverfasser:	Zarranz-Ventura, Javier, Fernández-Robredo, Patricia, Recalde, Sergio, Salinas-Alamán, Angel, Borrás-Cuesta, Francisco, Dotor, Javier, García-Layana, Alfredo
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Angiogenesis Angiography Animals Biochemical analysis Biology Choroidal Neovascularization - drug therapy Choroidal Neovascularization - metabolism Choroidal Neovascularization - pathology Cyclooxygenase 2 - genetics Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Cytokines Data processing Disease Progression Drugs Fluorescein Fluorescein Angiography Gelatin Gelatinase A Gelatinase B Gene expression Gene Expression Regulation - drug effects Hypotheses Inhibitors Insulin-like growth factor I Insulin-like growth factors Interleukin 6 Intravenous administration Laboratories Laser applications Lasers Lesions Macular degeneration Male Matrix Metalloproteinase 2 - metabolism Medicine Membranes Peptide Fragments - administration & dosage Peptide Fragments - pharmacology Peptides Peptides - administration & dosage Peptides - pharmacology Phosphorylation - drug effects Polyamide-imides Polymerase chain reaction Rats Receptors, Transforming Growth Factor beta - administration & dosage Retina Rodents Smad2 protein Smad2 Protein - metabolism Studies Transforming Growth Factor beta - antagonists & inhibitors Transforming Growth Factor beta - metabolism Transforming growth factor-b Tumor necrosis factor-TNF Tumor necrosis factor-α Vascular endothelial growth factor Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascularization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!