Increased levels of plasma soluble Sema4D in patients with heart failure

Semaphorin 4D (Sema4D/CD100) is a 150-kDa transmembrane glycoprotein expressed by platelets and T-cells. When these cells are activated, Sema4D is cleaved proteolytically, generating a biologically active 120-kDa fragment (soluble Sema4D) capable of targeting receptors on platelets, B-cells, endothe...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64265
Hauptverfasser:	Lu, Qiongyu, Dong, Ningzheng, Wang, Qi, Yi, Wenxiu, Wang, Yuxin, Zhang, Shengjie, Gu, Haibo, Zhao, Xin, Tang, Xiaorong, Jin, Boquan, Wu, Qingyu, Brass, Lawrence F, Zhu, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiogenesis Animals Antigens, CD - blood Antigens, CD - genetics Antigens, CD - immunology B-Lymphocytes - immunology B-Lymphocytes - pathology Beta cells Biological activity Biology Blood plasma Blood platelets Cardiology Case-Control Studies CD3 antigen CD3 Complex - genetics CD3 Complex - immunology CD4 antigen CD4 Antigens - genetics CD4 Antigens - immunology CD8 antigen CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Diabetes Diabetes Complications Diabetes mellitus Diabetes Mellitus - blood Diabetes Mellitus - immunology Diabetes Mellitus - pathology Endothelial cells Enzyme-linked immunosorbent assay Enzymes Female Gene Expression Glycoproteins Heart diseases Heart failure Heart Failure - blood Heart Failure - complications Heart Failure - immunology Heart Failure - pathology Hematology Hospitals Humans Kinases Lymphocyte Count Lymphocytes Lymphocytes T Male Medical prognosis Medicine Middle Aged Pancreatic cancer Patients Plasma levels Platelets Receptors Semaphorins - blood Semaphorins - genetics Semaphorins - immunology Sex Factors Studies TNF inhibitors Tumor cells Tumor necrosis factor-TNF
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