Brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6
Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heteroge...
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| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e64967-e64967 |
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| creator | Kuhl, Patricia K Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine |
| description | Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD. |
| doi_str_mv | 10.1371/journal.pone.0064967 |
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This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. 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ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23734230</pmid><doi>10.1371/journal.pone.0064967</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptation, Physiological - physiology Age Autism Babies Biology Brain Brain - physiopathology Brain research Child Child Development Disorders, Pervasive - physiopathology Child Development Disorders, Pervasive - psychology Child, Preschool Children Children & youth Cognition Cognition - physiology Cognitive ability Developmental disabilities Electroencephalography Event-related potentials Evoked Potentials - physiology Female Heterogeneity Humans Infant Laboratories Language Language acquisition Language Development Language Development Disorders - physiopathology Language Development Disorders - psychology Language thought relationship Linear Models Linguistics Male Medicine Native language acquisition Phonetics Predictions Psychiatry Receptive language Second language learning Social and Behavioral Sciences Social behavior Social factors Speech Studies Word processing |
| title | Brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6 |
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