Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development

Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepa...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64053-e64053
Hauptverfasser:	Lange, Christian M, Miki, Daiki, Ochi, Hidenori, Nischalke, Hans-Dieter, Bojunga, Jörg, Bibert, Stéphanie, Morikawa, Kenichi, Gouttenoire, Jérôme, Cerny, Andreas, Dufour, Jean-François, Gorgievski-Hrisoho, Meri, Heim, Markus H, Malinverni, Raffaele, Müllhaupt, Beat, Negro, Francesco, Semela, David, Kutalik, Zoltan, Müller, Tobias, Spengler, Ulrich, Berg, Thomas, Chayama, Kazuaki, Moradpour, Darius, Bochud, Pierre-Yves
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D 7-Dehydrocholesterol reductase Adolescent Adult Aged Antiviral Agents - therapeutic use Biology Biomedical research Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Child Cholestanetriol 26-Monooxygenase - genetics Cohort Studies Cytochrome P450 Family 2 Female Fibrosis Gastroenterology Gene Frequency Genetic analysis Genetic diversity Genomes Genotype Genotypes Hepacivirus Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatocellular carcinoma Hepatology Hospitals Humans Infectious diseases Interferon Internal medicine Laboratories Linkage Disequilibrium Liver Liver cancer Liver cirrhosis Liver Neoplasms - complications Liver Neoplasms - genetics Liver Neoplasms - virology Male Medicine Metabolism Metabolites Middle Aged Oxidoreductases Acting on CH-CH Group Donors - genetics Patients Polymorphism, Single Nucleotide Ribavirin Risk Science Serum levels Single-nucleotide polymorphism Squamous cell carcinoma Studies Viruses Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - genetics Vitamin D-Binding Protein - genetics Vitamin deficiency Young Adult
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