Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development
Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepa...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e64053-e64053 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e64053 |
|---|---|
| container_issue | 5 |
| container_start_page | e64053 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Lange, Christian M Miki, Daiki Ochi, Hidenori Nischalke, Hans-Dieter Bojunga, Jörg Bibert, Stéphanie Morikawa, Kenichi Gouttenoire, Jérôme Cerny, Andreas Dufour, Jean-François Gorgievski-Hrisoho, Meri Heim, Markus H Malinverni, Raffaele Müllhaupt, Beat Negro, Francesco Semela, David Kutalik, Zoltan Müller, Tobias Spengler, Ulrich Berg, Thomas Chayama, Kazuaki Moradpour, Darius Bochud, Pierre-Yves |
| description | Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).
Associations between CYP2R1, GC, and DHCR7 genotypes that are determinants of reduced 25-hydroxyvitamin D (25[OH]D3) serum levels and the risk of HCV-related HCC development were investigated for 1279 chronic hepatitis C patients with HCC and 4325 without HCC, respectively. The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes). In contrast, no association between these genetic variations and liver fibrosis progression rate (P>0.2 for each SNP) or outcome of standard therapy with pegylated interferon-α and ribavirin (P>0.2 for each SNP) was observed, suggesting a specific influence of the genetic determinants of 25(OH)D3 serum levels on hepatocarcinogenesis.
Our data suggest a relatively weak but functionally relevant role for vitamin D in the prevention of HCV-related hepatocarcinogenesis. |
| doi_str_mv | 10.1371/journal.pone.0064053 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1357024344</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_e963bbb7a51b4bcb81c9113e0b0e6429</doaj_id><sourcerecordid>2983101681</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-ea8e65d5b66755347af93f47bd9060b79af4a437623a02a3896c1e033aa1fcf43</originalsourceid><addsrcrecordid>eNptkktv1DAUhSMEoqXwDxBYYsMmgx0_kmyQqgHaSpXYAFvr2rlpPXLi1E5Gmn9P0kmrFrHy69zP91ydLHvP6Ibxkn3ZhSn24DdD6HFDqRJU8hfZKat5kauC8pdP9ifZm5R2dFZUSr3OTgpecsEqcZrdXWCPo7MEZtYhYSIR9wieAInBI2lDJHs3Qud68o24Pk1t66zD3h7mE7nc_skhpWAdjNiQWxxgDBa9nzxEYiFa14cOSDNDfRg67Me32asWfMJ363qW_f7x_df2Mr_-eXG1Pb_OrSzUmCNUqGQjjVKllFyU0Na8FaVpaqqoKWtoBQheqoIDLYBXtbIMKecArLWt4GfZxyN38CHpdVpJMy5LWgguFsXVUdEE2Okhug7iQQdw-v4ixBsNcZ6NR4214saYEiQzwlhTMVszxpEaikoU9cz6uv42mQ4bOxuN4J9Bn7_07lbfhL3msz96D_i8AmK4mzCNunNpmST0GKalbyWplEpVs_TTP9L_uxNHlY0hpYjtYzOM6iVBD1V6SZBeEzSXfXhq5LHoITL8LwHwxdM</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1357024344</pqid></control><display><type>article</type><title>Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development</title><source>Open Access: DOAJ - Directory of Open Access Journals</source><source>Open Access: PubMed Central</source><source>PLoS</source><source>MEDLINE</source><source>Full-Text Journals in Chemistry (Open access)</source><source>Free E-Journal (出版社公開部分のみ）</source><creator>Lange, Christian M ; Miki, Daiki ; Ochi, Hidenori ; Nischalke, Hans-Dieter ; Bojunga, Jörg ; Bibert, Stéphanie ; Morikawa, Kenichi ; Gouttenoire, Jérôme ; Cerny, Andreas ; Dufour, Jean-François ; Gorgievski-Hrisoho, Meri ; Heim, Markus H ; Malinverni, Raffaele ; Müllhaupt, Beat ; Negro, Francesco ; Semela, David ; Kutalik, Zoltan ; Müller, Tobias ; Spengler, Ulrich ; Berg, Thomas ; Chayama, Kazuaki ; Moradpour, Darius ; Bochud, Pierre-Yves</creator><creatorcontrib>Lange, Christian M ; Miki, Daiki ; Ochi, Hidenori ; Nischalke, Hans-Dieter ; Bojunga, Jörg ; Bibert, Stéphanie ; Morikawa, Kenichi ; Gouttenoire, Jérôme ; Cerny, Andreas ; Dufour, Jean-François ; Gorgievski-Hrisoho, Meri ; Heim, Markus H ; Malinverni, Raffaele ; Müllhaupt, Beat ; Negro, Francesco ; Semela, David ; Kutalik, Zoltan ; Müller, Tobias ; Spengler, Ulrich ; Berg, Thomas ; Chayama, Kazuaki ; Moradpour, Darius ; Bochud, Pierre-Yves ; Swiss Hepatitis C Cohort Study Group ; Hiroshima Liver Study Group ; the Swiss Hepatitis C Cohort Study Group ; the Hiroshima Liver Study Group</creatorcontrib><description>Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).
Associations between CYP2R1, GC, and DHCR7 genotypes that are determinants of reduced 25-hydroxyvitamin D (25[OH]D3) serum levels and the risk of HCV-related HCC development were investigated for 1279 chronic hepatitis C patients with HCC and 4325 without HCC, respectively. The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes). In contrast, no association between these genetic variations and liver fibrosis progression rate (P>0.2 for each SNP) or outcome of standard therapy with pegylated interferon-α and ribavirin (P>0.2 for each SNP) was observed, suggesting a specific influence of the genetic determinants of 25(OH)D3 serum levels on hepatocarcinogenesis.
Our data suggest a relatively weak but functionally relevant role for vitamin D in the prevention of HCV-related hepatocarcinogenesis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0064053</identifier><identifier>PMID: 23734184</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>25-Hydroxyvitamin D ; 7-Dehydrocholesterol reductase ; Adolescent ; Adult ; Aged ; Antiviral Agents - therapeutic use ; Biology ; Biomedical research ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - virology ; Child ; Cholestanetriol 26-Monooxygenase - genetics ; Cohort Studies ; Cytochrome P450 Family 2 ; Female ; Fibrosis ; Gastroenterology ; Gene Frequency ; Genetic analysis ; Genetic diversity ; Genomes ; Genotype ; Genotypes ; Hepacivirus ; Hepatitis ; Hepatitis C ; Hepatitis C, Chronic - complications ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - genetics ; Hepatocellular carcinoma ; Hepatology ; Hospitals ; Humans ; Infectious diseases ; Interferon ; Internal medicine ; Laboratories ; Linkage Disequilibrium ; Liver ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - complications ; Liver Neoplasms - genetics ; Liver Neoplasms - virology ; Male ; Medicine ; Metabolism ; Metabolites ; Middle Aged ; Oxidoreductases Acting on CH-CH Group Donors - genetics ; Patients ; Polymorphism, Single Nucleotide ; Ribavirin ; Risk ; Science ; Serum levels ; Single-nucleotide polymorphism ; Squamous cell carcinoma ; Studies ; Viruses ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - genetics ; Vitamin D-Binding Protein - genetics ; Vitamin deficiency ; Young Adult</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e64053-e64053</ispartof><rights>2013 Lange et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Lange et al 2013 Lange et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-ea8e65d5b66755347af93f47bd9060b79af4a437623a02a3896c1e033aa1fcf43</citedby><cites>FETCH-LOGICAL-c526t-ea8e65d5b66755347af93f47bd9060b79af4a437623a02a3896c1e033aa1fcf43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23734184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lange, Christian M</creatorcontrib><creatorcontrib>Miki, Daiki</creatorcontrib><creatorcontrib>Ochi, Hidenori</creatorcontrib><creatorcontrib>Nischalke, Hans-Dieter</creatorcontrib><creatorcontrib>Bojunga, Jörg</creatorcontrib><creatorcontrib>Bibert, Stéphanie</creatorcontrib><creatorcontrib>Morikawa, Kenichi</creatorcontrib><creatorcontrib>Gouttenoire, Jérôme</creatorcontrib><creatorcontrib>Cerny, Andreas</creatorcontrib><creatorcontrib>Dufour, Jean-François</creatorcontrib><creatorcontrib>Gorgievski-Hrisoho, Meri</creatorcontrib><creatorcontrib>Heim, Markus H</creatorcontrib><creatorcontrib>Malinverni, Raffaele</creatorcontrib><creatorcontrib>Müllhaupt, Beat</creatorcontrib><creatorcontrib>Negro, Francesco</creatorcontrib><creatorcontrib>Semela, David</creatorcontrib><creatorcontrib>Kutalik, Zoltan</creatorcontrib><creatorcontrib>Müller, Tobias</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><creatorcontrib>Berg, Thomas</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Moradpour, Darius</creatorcontrib><creatorcontrib>Bochud, Pierre-Yves</creatorcontrib><creatorcontrib>Swiss Hepatitis C Cohort Study Group</creatorcontrib><creatorcontrib>Hiroshima Liver Study Group</creatorcontrib><creatorcontrib>the Swiss Hepatitis C Cohort Study Group</creatorcontrib><creatorcontrib>the Hiroshima Liver Study Group</creatorcontrib><title>Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).
Associations between CYP2R1, GC, and DHCR7 genotypes that are determinants of reduced 25-hydroxyvitamin D (25[OH]D3) serum levels and the risk of HCV-related HCC development were investigated for 1279 chronic hepatitis C patients with HCC and 4325 without HCC, respectively. The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes). In contrast, no association between these genetic variations and liver fibrosis progression rate (P>0.2 for each SNP) or outcome of standard therapy with pegylated interferon-α and ribavirin (P>0.2 for each SNP) was observed, suggesting a specific influence of the genetic determinants of 25(OH)D3 serum levels on hepatocarcinogenesis.
Our data suggest a relatively weak but functionally relevant role for vitamin D in the prevention of HCV-related hepatocarcinogenesis.</description><subject>25-Hydroxyvitamin D</subject><subject>7-Dehydrocholesterol reductase</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Biology</subject><subject>Biomedical research</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Child</subject><subject>Cholestanetriol 26-Monooxygenase - genetics</subject><subject>Cohort Studies</subject><subject>Cytochrome P450 Family 2</subject><subject>Female</subject><subject>Fibrosis</subject><subject>Gastroenterology</subject><subject>Gene Frequency</subject><subject>Genetic analysis</subject><subject>Genetic diversity</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hepacivirus</subject><subject>Hepatitis</subject><subject>Hepatitis C</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - genetics</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon</subject><subject>Internal medicine</subject><subject>Laboratories</subject><subject>Linkage Disequilibrium</subject><subject>Liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - virology</subject><subject>Male</subject><subject>Medicine</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Oxidoreductases Acting on CH-CH Group Donors - genetics</subject><subject>Patients</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Ribavirin</subject><subject>Risk</subject><subject>Science</subject><subject>Serum levels</subject><subject>Single-nucleotide polymorphism</subject><subject>Squamous cell carcinoma</subject><subject>Studies</subject><subject>Viruses</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - genetics</subject><subject>Vitamin D-Binding Protein - genetics</subject><subject>Vitamin deficiency</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptkktv1DAUhSMEoqXwDxBYYsMmgx0_kmyQqgHaSpXYAFvr2rlpPXLi1E5Gmn9P0kmrFrHy69zP91ydLHvP6Ibxkn3ZhSn24DdD6HFDqRJU8hfZKat5kauC8pdP9ifZm5R2dFZUSr3OTgpecsEqcZrdXWCPo7MEZtYhYSIR9wieAInBI2lDJHs3Qud68o24Pk1t66zD3h7mE7nc_skhpWAdjNiQWxxgDBa9nzxEYiFa14cOSDNDfRg67Me32asWfMJ363qW_f7x_df2Mr_-eXG1Pb_OrSzUmCNUqGQjjVKllFyU0Na8FaVpaqqoKWtoBQheqoIDLYBXtbIMKecArLWt4GfZxyN38CHpdVpJMy5LWgguFsXVUdEE2Okhug7iQQdw-v4ixBsNcZ6NR4214saYEiQzwlhTMVszxpEaikoU9cz6uv42mQ4bOxuN4J9Bn7_07lbfhL3msz96D_i8AmK4mzCNunNpmST0GKalbyWplEpVs_TTP9L_uxNHlY0hpYjtYzOM6iVBD1V6SZBeEzSXfXhq5LHoITL8LwHwxdM</recordid><startdate>20130529</startdate><enddate>20130529</enddate><creator>Lange, Christian M</creator><creator>Miki, Daiki</creator><creator>Ochi, Hidenori</creator><creator>Nischalke, Hans-Dieter</creator><creator>Bojunga, Jörg</creator><creator>Bibert, Stéphanie</creator><creator>Morikawa, Kenichi</creator><creator>Gouttenoire, Jérôme</creator><creator>Cerny, Andreas</creator><creator>Dufour, Jean-François</creator><creator>Gorgievski-Hrisoho, Meri</creator><creator>Heim, Markus H</creator><creator>Malinverni, Raffaele</creator><creator>Müllhaupt, Beat</creator><creator>Negro, Francesco</creator><creator>Semela, David</creator><creator>Kutalik, Zoltan</creator><creator>Müller, Tobias</creator><creator>Spengler, Ulrich</creator><creator>Berg, Thomas</creator><creator>Chayama, Kazuaki</creator><creator>Moradpour, Darius</creator><creator>Bochud, Pierre-Yves</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130529</creationdate><title>Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development</title><author>Lange, Christian M ; Miki, Daiki ; Ochi, Hidenori ; Nischalke, Hans-Dieter ; Bojunga, Jörg ; Bibert, Stéphanie ; Morikawa, Kenichi ; Gouttenoire, Jérôme ; Cerny, Andreas ; Dufour, Jean-François ; Gorgievski-Hrisoho, Meri ; Heim, Markus H ; Malinverni, Raffaele ; Müllhaupt, Beat ; Negro, Francesco ; Semela, David ; Kutalik, Zoltan ; Müller, Tobias ; Spengler, Ulrich ; Berg, Thomas ; Chayama, Kazuaki ; Moradpour, Darius ; Bochud, Pierre-Yves</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-ea8e65d5b66755347af93f47bd9060b79af4a437623a02a3896c1e033aa1fcf43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>25-Hydroxyvitamin D</topic><topic>7-Dehydrocholesterol reductase</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Biology</topic><topic>Biomedical research</topic><topic>Carcinoma, Hepatocellular - complications</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Child</topic><topic>Cholestanetriol 26-Monooxygenase - genetics</topic><topic>Cohort Studies</topic><topic>Cytochrome P450 Family 2</topic><topic>Female</topic><topic>Fibrosis</topic><topic>Gastroenterology</topic><topic>Gene Frequency</topic><topic>Genetic analysis</topic><topic>Genetic diversity</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hepacivirus</topic><topic>Hepatitis</topic><topic>Hepatitis C</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - genetics</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon</topic><topic>Internal medicine</topic><topic>Laboratories</topic><topic>Linkage Disequilibrium</topic><topic>Liver</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - virology</topic><topic>Male</topic><topic>Medicine</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Oxidoreductases Acting on CH-CH Group Donors - genetics</topic><topic>Patients</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Ribavirin</topic><topic>Risk</topic><topic>Science</topic><topic>Serum levels</topic><topic>Single-nucleotide polymorphism</topic><topic>Squamous cell carcinoma</topic><topic>Studies</topic><topic>Viruses</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - genetics</topic><topic>Vitamin D-Binding Protein - genetics</topic><topic>Vitamin deficiency</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lange, Christian M</creatorcontrib><creatorcontrib>Miki, Daiki</creatorcontrib><creatorcontrib>Ochi, Hidenori</creatorcontrib><creatorcontrib>Nischalke, Hans-Dieter</creatorcontrib><creatorcontrib>Bojunga, Jörg</creatorcontrib><creatorcontrib>Bibert, Stéphanie</creatorcontrib><creatorcontrib>Morikawa, Kenichi</creatorcontrib><creatorcontrib>Gouttenoire, Jérôme</creatorcontrib><creatorcontrib>Cerny, Andreas</creatorcontrib><creatorcontrib>Dufour, Jean-François</creatorcontrib><creatorcontrib>Gorgievski-Hrisoho, Meri</creatorcontrib><creatorcontrib>Heim, Markus H</creatorcontrib><creatorcontrib>Malinverni, Raffaele</creatorcontrib><creatorcontrib>Müllhaupt, Beat</creatorcontrib><creatorcontrib>Negro, Francesco</creatorcontrib><creatorcontrib>Semela, David</creatorcontrib><creatorcontrib>Kutalik, Zoltan</creatorcontrib><creatorcontrib>Müller, Tobias</creatorcontrib><creatorcontrib>Spengler, Ulrich</creatorcontrib><creatorcontrib>Berg, Thomas</creatorcontrib><creatorcontrib>Chayama, Kazuaki</creatorcontrib><creatorcontrib>Moradpour, Darius</creatorcontrib><creatorcontrib>Bochud, Pierre-Yves</creatorcontrib><creatorcontrib>Swiss Hepatitis C Cohort Study Group</creatorcontrib><creatorcontrib>Hiroshima Liver Study Group</creatorcontrib><creatorcontrib>the Swiss Hepatitis C Cohort Study Group</creatorcontrib><creatorcontrib>the Hiroshima Liver Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest advanced technologies & aerospace journals</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lange, Christian M</au><au>Miki, Daiki</au><au>Ochi, Hidenori</au><au>Nischalke, Hans-Dieter</au><au>Bojunga, Jörg</au><au>Bibert, Stéphanie</au><au>Morikawa, Kenichi</au><au>Gouttenoire, Jérôme</au><au>Cerny, Andreas</au><au>Dufour, Jean-François</au><au>Gorgievski-Hrisoho, Meri</au><au>Heim, Markus H</au><au>Malinverni, Raffaele</au><au>Müllhaupt, Beat</au><au>Negro, Francesco</au><au>Semela, David</au><au>Kutalik, Zoltan</au><au>Müller, Tobias</au><au>Spengler, Ulrich</au><au>Berg, Thomas</au><au>Chayama, Kazuaki</au><au>Moradpour, Darius</au><au>Bochud, Pierre-Yves</au><aucorp>Swiss Hepatitis C Cohort Study Group</aucorp><aucorp>Hiroshima Liver Study Group</aucorp><aucorp>the Swiss Hepatitis C Cohort Study Group</aucorp><aucorp>the Hiroshima Liver Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-29</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e64053</spage><epage>e64053</epage><pages>e64053-e64053</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Vitamin D insufficiency has been associated with the occurrence of various types of cancer, but causal relationships remain elusive. We therefore aimed to determine the relationship between genetic determinants of vitamin D serum levels and the risk of developing hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).
Associations between CYP2R1, GC, and DHCR7 genotypes that are determinants of reduced 25-hydroxyvitamin D (25[OH]D3) serum levels and the risk of HCV-related HCC development were investigated for 1279 chronic hepatitis C patients with HCC and 4325 without HCC, respectively. The well-known associations between CYP2R1 (rs1993116, rs10741657), GC (rs2282679), and DHCR7 (rs7944926, rs12785878) genotypes and 25(OH)D3 serum levels were also apparent in patients with chronic hepatitis C. The same genotypes of these single nucleotide polymorphisms (SNPs) that are associated with reduced 25(OH)D3 serum levels were found to be associated with HCV-related HCC (P = 0.07 [OR = 1.13, 95% CI = 0.99-1.28] for CYP2R1, P = 0.007 [OR = 1.56, 95% CI = 1.12-2.15] for GC, P = 0.003 [OR = 1.42, 95% CI = 1.13-1.78] for DHCR7; ORs for risk genotypes). In contrast, no association between these genetic variations and liver fibrosis progression rate (P>0.2 for each SNP) or outcome of standard therapy with pegylated interferon-α and ribavirin (P>0.2 for each SNP) was observed, suggesting a specific influence of the genetic determinants of 25(OH)D3 serum levels on hepatocarcinogenesis.
Our data suggest a relatively weak but functionally relevant role for vitamin D in the prevention of HCV-related hepatocarcinogenesis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23734184</pmid><doi>10.1371/journal.pone.0064053</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5), p.e64053-e64053 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1357024344 |
| source | Open Access: DOAJ - Directory of Open Access Journals; Open Access: PubMed Central; PLoS; MEDLINE; Full-Text Journals in Chemistry (Open access); Free E-Journal (出版社公開部分のみ） |
| subjects | 25-Hydroxyvitamin D 7-Dehydrocholesterol reductase Adolescent Adult Aged Antiviral Agents - therapeutic use Biology Biomedical research Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Child Cholestanetriol 26-Monooxygenase - genetics Cohort Studies Cytochrome P450 Family 2 Female Fibrosis Gastroenterology Gene Frequency Genetic analysis Genetic diversity Genomes Genotype Genotypes Hepacivirus Hepatitis Hepatitis C Hepatitis C, Chronic - complications Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - genetics Hepatocellular carcinoma Hepatology Hospitals Humans Infectious diseases Interferon Internal medicine Laboratories Linkage Disequilibrium Liver Liver cancer Liver cirrhosis Liver Neoplasms - complications Liver Neoplasms - genetics Liver Neoplasms - virology Male Medicine Metabolism Metabolites Middle Aged Oxidoreductases Acting on CH-CH Group Donors - genetics Patients Polymorphism, Single Nucleotide Ribavirin Risk Science Serum levels Single-nucleotide polymorphism Squamous cell carcinoma Studies Viruses Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - genetics Vitamin D-Binding Protein - genetics Vitamin deficiency Young Adult |
| title | Genetic analyses reveal a role for vitamin D insufficiency in HCV-associated hepatocellular carcinoma development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T08%3A18%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20analyses%20reveal%20a%20role%20for%20vitamin%20D%20insufficiency%20in%20HCV-associated%20hepatocellular%20carcinoma%20development&rft.jtitle=PloS%20one&rft.au=Lange,%20Christian%20M&rft.aucorp=Swiss%20Hepatitis%20C%20Cohort%20Study%20Group&rft.date=2013-05-29&rft.volume=8&rft.issue=5&rft.spage=e64053&rft.epage=e64053&rft.pages=e64053-e64053&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0064053&rft_dat=%3Cproquest_plos_%3E2983101681%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1357024344&rft_id=info:pmid/23734184&rft_doaj_id=oai_doaj_org_article_e963bbb7a51b4bcb81c9113e0b0e6429&rfr_iscdi=true |