Frequent occurrence of highly expanded but unrelated B-cell clones in patients with multiple myeloma

Clonal diversity in multiple myeloma (MM) includes both MM-related and MM-unrelated clonal expansions which are subject to dominance exerted by the MM clone. Here we show evidence for the existence of minor but highly expanded unrelated B-cell clones in patients with MM defined by their complementar...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64927-e64927
Hauptverfasser:	Kriangkum, Jitra, Motz, Sarah N, Debes Marun, Carina S, Lafarge, Sandrine T, Gibson, Spencer B, Venner, Christopher P, Johnston, James B, Belch, Andrew R, Pilarski, Linda M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens Antigens - immunology B-Lymphocytes - immunology B-Lymphocytes - pathology Benign monoclonal gammopathy Biology Cancer therapies Cell Proliferation Chromosomes, Human - genetics Chronic lymphocytic leukemia Clone Cells Cloning Complementarity Determining Regions - chemistry Complementarity Determining Regions - immunology Complementarity-determining region 3 Deoxyribonucleic acid Disease Progression DNA DNA Fragmentation Dominance Gene Rearrangement, B-Lymphocyte, Heavy Chain Heavy chains Hepatitis Humans Immunoglobulins Immunology In Situ Hybridization, Fluorescence Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Lymphatic leukemia Lymphocytes B Lymphoma Medical treatment Medicine Molecular Sequence Data Multiple myeloma Multiple Myeloma - immunology Multiple Myeloma - pathology Mutation Oncology Patients Polymerase chain reaction V(D)J Recombination - immunology
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