Epigenetic upregulation of HGF and c-Met drives metastasis in hepatocellular carcinoma

Hepatocyte growth factor (HGF) and its receptor, c-Met, are important regulators of growth and differentiation of healthy hepatocytes. However, upregulation of HGF and c-Met have been associated with tumor progression and metastasis in hepatocellular carcinoma (HCC). Hematogenous dissemination is th...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63765
Hauptverfasser:	Ogunwobi, Olorunseun O, Puszyk, William, Dong, Hui-Jia, Liu, Chen
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Animals Base Sequence Biology Blood circulation c-Met protein Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell culture Cell Line, Tumor CpG islands Demethylation Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetics Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Hepatocellular carcinoma Hepatocyte growth factor Hepatocyte Growth Factor - genetics Hepatocytes Hepatology Humans Immunology Laboratories Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Medical prognosis Medical research Medicine Mesenchyme Mesoderm - pathology Metastases Metastasis Mice Mice, Inbred BALB C Models, Biological Molecular Sequence Data Mortality Neoplastic Cells, Circulating - metabolism Neoplastic Cells, Circulating - pathology Pathology Peripheral blood Promoter Regions, Genetic - genetics Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Regulators Studies Therapeutic applications Tumor cell lines Tumor cells Tumorigenicity Up-regulation Up-Regulation - genetics
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