Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction
Interstitial fibrosis is regarded as the main pathway for the progression of chronic kidney disease (CKD) and is often associated with severe renal dysfunction. Stem cell-based therapies may provide alternative approaches for the treatment of CKD. Human amniotic fluid-derived stem cells (hAFSCs) are...
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| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e65042-e65042 |
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| creator | Sun, Dong Bu, Lin Liu, Caixia Yin, Zhongcheng Zhou, Xudong Li, Xiaoju Xiao, Aiguo |
| description | Interstitial fibrosis is regarded as the main pathway for the progression of chronic kidney disease (CKD) and is often associated with severe renal dysfunction. Stem cell-based therapies may provide alternative approaches for the treatment of CKD. Human amniotic fluid-derived stem cells (hAFSCs) are a novel stem cell population, which exhibit both embryonic and mesenchymal stem cell characteristics. Herein, the present study investigated whether the transplantation of hAFSCs into renal tissues could improve renal interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). We showed that hAFSCs provided a protective effect and alleviated interstitial fibrosis as reflected by an increase in microvascular density; additionally, hAFSCs treatment beneficially modulated protein levels of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α) and transforming growth factor-β1 (TGF-β1). Therefore, we hypothesize that hAFSCs could represent an alternative, readily available source of stem cells that can be applied for the treatment of renal interstitial fibrosis. |
| doi_str_mv | 10.1371/journal.pone.0065042 |
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Stem cell-based therapies may provide alternative approaches for the treatment of CKD. Human amniotic fluid-derived stem cells (hAFSCs) are a novel stem cell population, which exhibit both embryonic and mesenchymal stem cell characteristics. Herein, the present study investigated whether the transplantation of hAFSCs into renal tissues could improve renal interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). We showed that hAFSCs provided a protective effect and alleviated interstitial fibrosis as reflected by an increase in microvascular density; additionally, hAFSCs treatment beneficially modulated protein levels of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α) and transforming growth factor-β1 (TGF-β1). Therefore, we hypothesize that hAFSCs could represent an alternative, readily available source of stem cells that can be applied for the treatment of renal interstitial fibrosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0065042</identifier><identifier>PMID: 23724119</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amniotic fluid ; Amniotic Fluid - cytology ; Animal models ; Animals ; Apoptosis ; Biology ; Cadherins - metabolism ; Capillaries - pathology ; Cell Proliferation ; Cell Shape ; Cells, Cultured ; Chemokine CCL2 - metabolism ; Collagen Type I - metabolism ; Disease Models, Animal ; Fibrosis ; Growth factors ; Hospitals ; Humans ; Hypoxia ; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism ; In Situ Nick-End Labeling ; Ki-67 Antigen - metabolism ; Kidney Diseases - complications ; Kidney Diseases - pathology ; Kidney Diseases - therapy ; Kidney transplantation ; Kidney Tubules - blood supply ; Kidney Tubules - pathology ; Kidneys ; Laboratory animals ; Medicine ; Mesenchyme ; Mice ; Microvasculature ; Morphology ; Nephrology ; Phenotype ; Proliferating Cell Nuclear Antigen - metabolism ; Renal function ; Rodents ; Stem Cell Transplantation ; Stem cells ; Stem Cells - cytology ; Tissues ; Transforming growth factor ; Transforming Growth Factor beta1 - metabolism ; Transforming growth factor-b1 ; Transplantation ; Ureteral Obstruction - complications ; Ureteral Obstruction - pathology ; Ureteral Obstruction - therapy ; Vascular endothelial growth factor ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e65042-e65042</ispartof><rights>2013 Sun et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Sun et al 2013 Sun et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c592t-111b07c9a027c9fe5c65811359b0b0080cb54d0cc65b7321823d76a82ddc86cf3</citedby><cites>FETCH-LOGICAL-c592t-111b07c9a027c9fe5c65811359b0b0080cb54d0cc65b7321823d76a82ddc86cf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665750/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665750/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,2098,2917,23849,27907,27908,53774,53776,79351,79352</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23724119$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Chatziantoniou, Christos</contributor><creatorcontrib>Sun, Dong</creatorcontrib><creatorcontrib>Bu, Lin</creatorcontrib><creatorcontrib>Liu, Caixia</creatorcontrib><creatorcontrib>Yin, Zhongcheng</creatorcontrib><creatorcontrib>Zhou, Xudong</creatorcontrib><creatorcontrib>Li, Xiaoju</creatorcontrib><creatorcontrib>Xiao, Aiguo</creatorcontrib><title>Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Interstitial fibrosis is regarded as the main pathway for the progression of chronic kidney disease (CKD) and is often associated with severe renal dysfunction. Stem cell-based therapies may provide alternative approaches for the treatment of CKD. Human amniotic fluid-derived stem cells (hAFSCs) are a novel stem cell population, which exhibit both embryonic and mesenchymal stem cell characteristics. Herein, the present study investigated whether the transplantation of hAFSCs into renal tissues could improve renal interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). We showed that hAFSCs provided a protective effect and alleviated interstitial fibrosis as reflected by an increase in microvascular density; additionally, hAFSCs treatment beneficially modulated protein levels of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α) and transforming growth factor-β1 (TGF-β1). Therefore, we hypothesize that hAFSCs could represent an alternative, readily available source of stem cells that can be applied for the treatment of renal interstitial fibrosis.</description><subject>Amniotic fluid</subject><subject>Amniotic Fluid - cytology</subject><subject>Animal models</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biology</subject><subject>Cadherins - metabolism</subject><subject>Capillaries - pathology</subject><subject>Cell Proliferation</subject><subject>Cell Shape</subject><subject>Cells, Cultured</subject><subject>Chemokine CCL2 - metabolism</subject><subject>Collagen Type I - metabolism</subject><subject>Disease Models, Animal</subject><subject>Fibrosis</subject><subject>Growth factors</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Hypoxia-Inducible Factor 1, alpha Subunit - metabolism</subject><subject>In Situ Nick-End Labeling</subject><subject>Ki-67 Antigen - metabolism</subject><subject>Kidney Diseases - 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pathology</subject><subject>Ureteral Obstruction - therapy</subject><subject>Vascular endothelial growth factor</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUsluFDEQbSEQSQb-AIElLrnM4KVtd1-QUMQSKRKXcLbcdnXGo2578BIpv8EX48l0ogRxsctVr55reU3zjuANYZJ82oUSvZ42--Bhg7HguKUvmlPSM7oWFLOXT-yT5iylHcacdUK8bk4ok7QlpD9t_lxvIeo9lOwMgnEEkxMKI9qWWXukZ-_CITJOxdm1hehuwaKUYUYGpqlCPYpQy0DOZ4gpu-zqY3RDDMml6kUazSU6D2gOFqYDd_Fu0hVdgSXC0QhDyrGY7IJ_07wa9ZTg7XKvml_fvl5f_Fhf_fx-efHlam14T_OaEDJgaXqNaT1H4EbwjhDG-wEPGHfYDLy12FT3IBklHWVWCt1Ra00nzMhWzYcj734KSS3jTKoy8B5LWvGr5vKIsEHv1D66Wcc7FbRT944Qb5SOdTwTKGEot0AkSCpba0hPadfRvmtHivUgTeX6vPxWhhmsAZ9r389In0e826qbcKuYEFxyXAnOF4IYfhdIWc0uHZagPYRyX7ds-x4LUqEf_4H-v7v2iDJ1VynC-FgMweogsYcsdZCYWiRW094_beQx6UFT7C-o0NIv</recordid><startdate>20130528</startdate><enddate>20130528</enddate><creator>Sun, Dong</creator><creator>Bu, Lin</creator><creator>Liu, Caixia</creator><creator>Yin, Zhongcheng</creator><creator>Zhou, Xudong</creator><creator>Li, Xiaoju</creator><creator>Xiao, Aiguo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130528</creationdate><title>Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction</title><author>Sun, Dong ; Bu, Lin ; Liu, Caixia ; Yin, Zhongcheng ; Zhou, Xudong ; Li, Xiaoju ; Xiao, Aiguo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c592t-111b07c9a027c9fe5c65811359b0b0080cb54d0cc65b7321823d76a82ddc86cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amniotic fluid</topic><topic>Amniotic Fluid - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Dong</au><au>Bu, Lin</au><au>Liu, Caixia</au><au>Yin, Zhongcheng</au><au>Zhou, Xudong</au><au>Li, Xiaoju</au><au>Xiao, Aiguo</au><au>Chatziantoniou, Christos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-28</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e65042</spage><epage>e65042</epage><pages>e65042-e65042</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Interstitial fibrosis is regarded as the main pathway for the progression of chronic kidney disease (CKD) and is often associated with severe renal dysfunction. Stem cell-based therapies may provide alternative approaches for the treatment of CKD. Human amniotic fluid-derived stem cells (hAFSCs) are a novel stem cell population, which exhibit both embryonic and mesenchymal stem cell characteristics. Herein, the present study investigated whether the transplantation of hAFSCs into renal tissues could improve renal interstitial fibrosis in a murine model of unilateral ureteral obstruction (UUO). We showed that hAFSCs provided a protective effect and alleviated interstitial fibrosis as reflected by an increase in microvascular density; additionally, hAFSCs treatment beneficially modulated protein levels of vascular endothelial growth factor (VEGF), hypoxia inducible factor-1α (HIF-1α) and transforming growth factor-β1 (TGF-β1). Therefore, we hypothesize that hAFSCs could represent an alternative, readily available source of stem cells that can be applied for the treatment of renal interstitial fibrosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23724119</pmid><doi>10.1371/journal.pone.0065042</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Amniotic fluid Amniotic Fluid - cytology Animal models Animals Apoptosis Biology Cadherins - metabolism Capillaries - pathology Cell Proliferation Cell Shape Cells, Cultured Chemokine CCL2 - metabolism Collagen Type I - metabolism Disease Models, Animal Fibrosis Growth factors Hospitals Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism In Situ Nick-End Labeling Ki-67 Antigen - metabolism Kidney Diseases - complications Kidney Diseases - pathology Kidney Diseases - therapy Kidney transplantation Kidney Tubules - blood supply Kidney Tubules - pathology Kidneys Laboratory animals Medicine Mesenchyme Mice Microvasculature Morphology Nephrology Phenotype Proliferating Cell Nuclear Antigen - metabolism Renal function Rodents Stem Cell Transplantation Stem cells Stem Cells - cytology Tissues Transforming growth factor Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Transplantation Ureteral Obstruction - complications Ureteral Obstruction - pathology Ureteral Obstruction - therapy Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism |
| title | Therapeutic effects of human amniotic fluid-derived stem cells on renal interstitial fibrosis in a murine model of unilateral ureteral obstruction |
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