Induction of interferon-stimulated genes on the IL-4 response axis by Epstein-Barr virus infected human b cells; relevance to cellular transformation

Epstein-Barr virus (EBV) is an oncogenic virus that is associated with the pathogenesis of several human lymphoid malignancies, including Hodgkin's lymphoma. Infection of normal resting B cells with EBV results in activation to lymphoblasts that are phenotypically similar to those generated by...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64868
Hauptverfasser:	Smith, Nikki, Tierney, Rosemary, Wei, Wenbin, Vockerodt, Martina, Murray, Paul G, Woodman, Ciaran B, Rowe, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis B-Lymphocytes - metabolism B-Lymphocytes - pathology B-Lymphocytes - virology Biology Biotechnology Blood & organ donations Cancer CD40 Ligand - immunology CD40 Ligand - pharmacology CD40L protein Cell activation Cell culture Cell Line, Tumor Cell proliferation Cell Transformation, Viral - drug effects Cell Transformation, Viral - genetics Cytokines Disease Epstein-Barr virus Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Genes Genetic transformation Herpesvirus 4, Human - physiology Hodgkin Disease - genetics Hodgkin Disease - metabolism Humans Infections Interferon Interferon Regulatory Factors - genetics Interferons - metabolism Interleukin 4 Interleukin-4 - metabolism Interleukin-4 - pharmacology Lymphoblastoid cell lines Lymphoblasts Lymphocyte Activation - drug effects Lymphocyte Activation - genetics Lymphocyte Activation - immunology Lymphocyte receptors Lymphocytes Lymphocytes B Lymphoma Lymphomas Malignancy Medical research Medicine Pathogenesis Proteins Signal Transduction Stimulation Transcription Transcriptome Transformation Tumors Viral Matrix Proteins - metabolism Virology Viruses
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