Association between HIF1A P582S and A588T polymorphisms and the risk of urinary cancers: a meta-analysis

The hypoxia-inducible factor-1 alpha (HIF1A) plays a vital role in cancer initiation and progression. Previous studies have reported the existence of HIF1A P582S and A588T missense polymorphisms in renal, urothelial and prostatic carcinomas, however the effects remain conflicting. Therefore, we perf...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63445
Hauptverfasser:	Li, Dawei, Liu, Jikai, Zhang, Wenhua, Ren, Juchao, Yan, Lei, Liu, Hainan, Xu, Zhonghua
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution Biology Cancer Case-Control Studies Computer programs Confidence intervals Gene Frequency Gene polymorphism Genetic Association Studies Genetic Predisposition to Disease Genotypes Health risks Humans Hypoxia Hypoxia-inducible factor 1 Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-inducible factor 1a Kidney cancer Kidneys Male Medical prognosis Medicine Meta-analysis Mutation Polymorphism Polymorphism, Single Nucleotide Population genetics Prostate cancer Prostatic Neoplasms - genetics Proteins Risk Risk Factors Studies Urogenital Neoplasms - genetics Urology Urothelial carcinoma
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