Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers

Dietary supplementation of selenium and green tea holds promise in cancer prevention. In this study, we evaluated the efficacies of selenium and green tea administered individually and in combination against colorectal cancer in an azoxymethane (AOM)-induced rat colonic carcinogenesis model and dete...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64362
Hauptverfasser:	Hu, Ying, McIntosh, Graeme H, Le Leu, Richard K, Nyskohus, Laura S, Woodman, Richard J, Young, Graeme P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Acetylation Administration, Oral Animals Anticarcinogenic Agents - administration & dosage Anticarcinogenic Agents - pharmacology Azoxymethane Biological markers Biology Biomarkers Cancer Cancer prevention Cancer research Carcinogenesis Carcinogens Catenin Cell Proliferation Chemistry Chemoprevention Chemotherapy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - chemically induced Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Colorectal Neoplasms - prevention & control Crypts Cyclin D1 Cyclooxygenase 2 - metabolism Cyclooxygenase-2 Diet Dietary Supplements DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNMT1 protein Epigenesis, Genetic - drug effects Epigenetic inheritance Epigenetics Gene expression Genetic aspects Genetic Markers Green tea Histone H3 Histones - metabolism Inhibition Ki-67 Antigen - metabolism Male Medicine Methyltransferases Milk Milk proteins mRNA Nuclear transport Plant Extracts - administration & dosage Plant Extracts - pharmacology Protein Processing, Post-Translational Proteins Rats Rats, Sprague-Dawley Restoration RNA Rodents Selenium Selenium (Chemical element) Selenium - administration & dosage Selenium - pharmacology Tea Translocation Tumor Burden Tumorigenesis Tumors
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