Effects of gender and age on development of concurrent extrapulmonary tuberculosis in patients with pulmonary tuberculosis: a population based study
Most cases of adult-onset tuberculosis (TB) result from reactivation of a pre-existing Mycobacterium tuberculosis infection. Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pul...
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| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e63936-e63936 |
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| description | Most cases of adult-onset tuberculosis (TB) result from reactivation of a pre-existing Mycobacterium tuberculosis infection. Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pulmonary TB. The purpose of the present study was to identify the demographic and clinical factors associated with an increased risk of concurrent extra-pulmonary diseases in patients with pulmonary TB. We compared patients who had isolated pulmonary TB with patients who had concurrent pulmonary and extra-pulmonary TB. We initially analyzed one-million randomly selected subjects from the population-based Taiwan National Health Insurance database. Based on analysis of 5414 pulmonary TB patients in this database, women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.30, p = 0.013). A separate analysis of the Kaohsiung Medical University Hospital database, which relied on sputum culture-proven pulmonary TB, indicated that women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.62, p = 0.039). There was no significant gender difference in extra-pulmonary TB for patients younger than 45 years in either database. However, for patients 45 years and older, women were more likely than men to have concurrent extra-pulmonary TB (insurance database: 9.0% vs. 6.8%, p = 0.016, OR: 1.36; hospital database: 27.3% vs. 16.0%, p = 0.008, OR = 1.98). Our results indicate that among patients who have pulmonary TB, older females have an increased risk for concurrent extra-pulmonary TB. |
| doi_str_mv | 10.1371/journal.pone.0063936 |
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Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pulmonary TB. The purpose of the present study was to identify the demographic and clinical factors associated with an increased risk of concurrent extra-pulmonary diseases in patients with pulmonary TB. We compared patients who had isolated pulmonary TB with patients who had concurrent pulmonary and extra-pulmonary TB. We initially analyzed one-million randomly selected subjects from the population-based Taiwan National Health Insurance database. Based on analysis of 5414 pulmonary TB patients in this database, women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.30, p = 0.013). A separate analysis of the Kaohsiung Medical University Hospital database, which relied on sputum culture-proven pulmonary TB, indicated that women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.62, p = 0.039). There was no significant gender difference in extra-pulmonary TB for patients younger than 45 years in either database. However, for patients 45 years and older, women were more likely than men to have concurrent extra-pulmonary TB (insurance database: 9.0% vs. 6.8%, p = 0.016, OR: 1.36; hospital database: 27.3% vs. 16.0%, p = 0.008, OR = 1.98). Our results indicate that among patients who have pulmonary TB, older females have an increased risk for concurrent extra-pulmonary TB.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0063936</identifier><identifier>PMID: 23717513</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; Activation ; Adolescent ; Adult ; Age Distribution ; Aged ; Aged, 80 and over ; AIDS ; Analysis ; Care and treatment ; Child ; Child, Preschool ; Data bases ; Demographics ; Epidemiology ; Female ; Females ; Gender Identity ; Health insurance ; Health risks ; HIV ; Human immunodeficiency virus ; Humans ; Infant ; Infant, Newborn ; Insurance ; Lung diseases ; Male ; Medical diagnosis ; Medical research ; Medicine ; Men ; Middle Aged ; Mycobacterium tuberculosis ; National health insurance ; Patients ; Population studies ; Population-based studies ; Respiratory tract ; Risk ; Sputum ; Studies ; Taiwan - epidemiology ; Tuberculosis ; Tuberculosis - epidemiology ; Tuberculosis - etiology ; Tuberculosis - microbiology ; Tuberculosis, Pulmonary - complications ; Young Adult</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e63936-e63936</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Lin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Lin et al 2013 Lin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6076-c63d57278f353ed7da6d50aee07604032490ee02c061f224f418981c0d88f7103</citedby><cites>FETCH-LOGICAL-c6076-c63d57278f353ed7da6d50aee07604032490ee02c061f224f418981c0d88f7103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661599/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661599/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23717513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Chun-Yu</creatorcontrib><creatorcontrib>Chen, Tun-Chieh</creatorcontrib><creatorcontrib>Lu, Po-Liang</creatorcontrib><creatorcontrib>Lai, Chung-Chih</creatorcontrib><creatorcontrib>Yang, Yi-Hsin</creatorcontrib><creatorcontrib>Lin, Wei-Ru</creatorcontrib><creatorcontrib>Huang, Pei-Ming</creatorcontrib><creatorcontrib>Chen, Yen-Hsu</creatorcontrib><title>Effects of gender and age on development of concurrent extrapulmonary tuberculosis in patients with pulmonary tuberculosis: a population based study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Most cases of adult-onset tuberculosis (TB) result from reactivation of a pre-existing Mycobacterium tuberculosis infection. Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pulmonary TB. The purpose of the present study was to identify the demographic and clinical factors associated with an increased risk of concurrent extra-pulmonary diseases in patients with pulmonary TB. We compared patients who had isolated pulmonary TB with patients who had concurrent pulmonary and extra-pulmonary TB. We initially analyzed one-million randomly selected subjects from the population-based Taiwan National Health Insurance database. Based on analysis of 5414 pulmonary TB patients in this database, women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.30, p = 0.013). A separate analysis of the Kaohsiung Medical University Hospital database, which relied on sputum culture-proven pulmonary TB, indicated that women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.62, p = 0.039). There was no significant gender difference in extra-pulmonary TB for patients younger than 45 years in either database. However, for patients 45 years and older, women were more likely than men to have concurrent extra-pulmonary TB (insurance database: 9.0% vs. 6.8%, p = 0.016, OR: 1.36; hospital database: 27.3% vs. 16.0%, p = 0.008, OR = 1.98). Our results indicate that among patients who have pulmonary TB, older females have an increased risk for concurrent extra-pulmonary TB.</description><subject>Acquired immune deficiency syndrome</subject><subject>Activation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIDS</subject><subject>Analysis</subject><subject>Care and treatment</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Data bases</subject><subject>Demographics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Females</subject><subject>Gender Identity</subject><subject>Health insurance</subject><subject>Health risks</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Insurance</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>National health insurance</subject><subject>Patients</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Respiratory tract</subject><subject>Risk</subject><subject>Sputum</subject><subject>Studies</subject><subject>Taiwan - epidemiology</subject><subject>Tuberculosis</subject><subject>Tuberculosis - epidemiology</subject><subject>Tuberculosis - etiology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis, Pulmonary - complications</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1uL1DAUx4so7jr6DUQDgujDjEnTJq0PwrKsOrCw4O01pLl0MnSamrSr-z38wJ7udJepzIMU2lx-538uPSdJnhO8IpSTd1s_hFY2q863ZoUxoyVlD5JTUtJ0yVJMHx6sT5InMW4xzmnB2OPkJAUBnhN6mvy5sNaoPiJvUW1abQKSrUayNsi3SJtr0_huZ9p-BJRv1RDCuDO_-yC7odn5VoYb1A-VCWpofHQRuRZ1sneARfTL9Rt0nHuPJOo83AELvioZjUaxH_TN0-SRlU00z6bvIvn-8eLb-efl5dWn9fnZ5VIxzBm8qc55ygtLc2o015LpHEtj4BJnmKZZiWGTKsyITdPMZqQoC6KwLgrLCaaL5OVet4OAxFTQKAjNM0p5VlAg1ntCe7kVXXA7yEJ46cTtgQ-1kKF3qjFCV4QzVlmeVzSzEAerMqo5ZSUvq3G9SD5M3oZqZ7SC-gTZzETnN63biNpfC8oYycsSBN5MAsH_HEzsxc5FZZpGtsYPt3GzMs9pxgB99Q96PLuJqiUk4Frrwa8aRcVZxgvCcqgiUKsjFDza7By0hLEOzmcGb2cGwPTQL7UcYhTrr1_-n736MWdfH7AbI5t-E30zjO0T52C2B1XwMQZj74tMsBiH564aYhweMQ0PmL04_EH3RnfTQv8CdecWmw</recordid><startdate>20130522</startdate><enddate>20130522</enddate><creator>Lin, Chun-Yu</creator><creator>Chen, Tun-Chieh</creator><creator>Lu, Po-Liang</creator><creator>Lai, Chung-Chih</creator><creator>Yang, Yi-Hsin</creator><creator>Lin, Wei-Ru</creator><creator>Huang, Pei-Ming</creator><creator>Chen, Yen-Hsu</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130522</creationdate><title>Effects of gender and age on development of concurrent extrapulmonary tuberculosis in patients with pulmonary tuberculosis: a population based study</title><author>Lin, Chun-Yu ; Chen, Tun-Chieh ; Lu, Po-Liang ; Lai, Chung-Chih ; Yang, Yi-Hsin ; Lin, Wei-Ru ; Huang, Pei-Ming ; Chen, Yen-Hsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6076-c63d57278f353ed7da6d50aee07604032490ee02c061f224f418981c0d88f7103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Activation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIDS</topic><topic>Analysis</topic><topic>Care and treatment</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Data bases</topic><topic>Demographics</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Females</topic><topic>Gender Identity</topic><topic>Health insurance</topic><topic>Health risks</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Insurance</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>National health insurance</topic><topic>Patients</topic><topic>Population studies</topic><topic>Population-based studies</topic><topic>Respiratory tract</topic><topic>Risk</topic><topic>Sputum</topic><topic>Studies</topic><topic>Taiwan - 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Mycobacterium tuberculosis usually invades the respiratory tract and most patients develop intrapulmonary TB; however, some patients develop concurrent pulmonary and extra-pulmonary TB. The purpose of the present study was to identify the demographic and clinical factors associated with an increased risk of concurrent extra-pulmonary diseases in patients with pulmonary TB. We compared patients who had isolated pulmonary TB with patients who had concurrent pulmonary and extra-pulmonary TB. We initially analyzed one-million randomly selected subjects from the population-based Taiwan National Health Insurance database. Based on analysis of 5414 pulmonary TB patients in this database, women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.30, p = 0.013). A separate analysis of the Kaohsiung Medical University Hospital database, which relied on sputum culture-proven pulmonary TB, indicated that women were more likely than men to have concurrent extra-pulmonary TB (OR: 1.62, p = 0.039). There was no significant gender difference in extra-pulmonary TB for patients younger than 45 years in either database. However, for patients 45 years and older, women were more likely than men to have concurrent extra-pulmonary TB (insurance database: 9.0% vs. 6.8%, p = 0.016, OR: 1.36; hospital database: 27.3% vs. 16.0%, p = 0.008, OR = 1.98). Our results indicate that among patients who have pulmonary TB, older females have an increased risk for concurrent extra-pulmonary TB.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23717513</pmid><doi>10.1371/journal.pone.0063936</doi><tpages>e63936</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5), p.e63936-e63936 |
| issn | 1932-6203 1932-6203 |
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| subjects | Acquired immune deficiency syndrome Activation Adolescent Adult Age Distribution Aged Aged, 80 and over AIDS Analysis Care and treatment Child Child, Preschool Data bases Demographics Epidemiology Female Females Gender Identity Health insurance Health risks HIV Human immunodeficiency virus Humans Infant Infant, Newborn Insurance Lung diseases Male Medical diagnosis Medical research Medicine Men Middle Aged Mycobacterium tuberculosis National health insurance Patients Population studies Population-based studies Respiratory tract Risk Sputum Studies Taiwan - epidemiology Tuberculosis Tuberculosis - epidemiology Tuberculosis - etiology Tuberculosis - microbiology Tuberculosis, Pulmonary - complications Young Adult |
| title | Effects of gender and age on development of concurrent extrapulmonary tuberculosis in patients with pulmonary tuberculosis: a population based study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T16%3A49%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20gender%20and%20age%20on%20development%20of%20concurrent%20extrapulmonary%20tuberculosis%20in%20patients%20with%20pulmonary%20tuberculosis:%20a%20population%20based%20study&rft.jtitle=PloS%20one&rft.au=Lin,%20Chun-Yu&rft.date=2013-05-22&rft.volume=8&rft.issue=5&rft.spage=e63936&rft.epage=e63936&rft.pages=e63936-e63936&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0063936&rft_dat=%3Cgale_plos_%3EA478165403%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1354337483&rft_id=info:pmid/23717513&rft_galeid=A478165403&rft_doaj_id=oai_doaj_org_article_db1766bf75b34f50a6b43d736979b6b4&rfr_iscdi=true |