Real-time imaging of NADPH oxidase activity in living cells using a novel fluorescent protein reporter

Production of reactive oxygen species (ROS) has been implicated in the pathology of many conditions, including cardiovascular, inflammatory and degenerative diseases, aging, muscular dystrophy, and muscle fatigue. NADPH oxidases (Nox) have recently gained attention as an important source of ROS invo...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63989-e63989
Hauptverfasser:	Pal, Rituraj, Basu Thakur, Poulami, Li, Shumin, Minard, Charles, Rodney, George G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biology Biophysics Biosensing Techniques Biosensors Cell Survival - drug effects Cloning Computer Systems Degenerative diseases Deoxyribonucleic acid DNA Dystrophy Electric Stimulation Electrical stimuli Extracellular Space - drug effects Extracellular Space - metabolism Fatigue Fibroblasts Fluorescence Free radicals Genes, Reporter Green Fluorescent Proteins - metabolism Humans In Vitro Techniques Journalists Kinases Laboratory animals Lipopolysaccharides - pharmacology Macrophage Activation - drug effects Macrophages Medicine Membrane Glycoproteins - deficiency Membrane Glycoproteins - metabolism Mice Mitochondria Molecular Imaging - methods Muscle Fibers, Skeletal - drug effects Muscle Fibers, Skeletal - enzymology Muscles Muscular dystrophy Muscular fatigue Musculoskeletal system NAD(P)H oxidase NADPH Oxidase 2 NADPH Oxidases - deficiency NADPH Oxidases - metabolism Oxidases Oxidation Oxidation-Reduction - drug effects Oxygen Penicillin Physiology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signaling Skeletal muscle Spatial discrimination Spatial resolution Stimulation Time Factors
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