Stretch-sensitive down-regulation of the miR-144/451 cluster in vascular smooth muscle and its role in AMP-activated protein kinase signaling

Vascular smooth muscle cells are constantly exposed to mechanical force by the blood pressure, which is thought to regulate smooth muscle growth, differentiation and contractile function. We have previously shown that the expression of microRNAs (miRNAs), small non-coding RNAs, is essential for regu...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e65135
Hauptverfasser:	Turczyńska, Karolina M, Bhattachariya, Anirban, Säll, Johanna, Göransson, Olga, Swärd, Karl, Hellstrand, Per, Albinsson, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aminoimidazole Carboxamide - analogs & derivatives Aminoimidazole Carboxamide - pharmacology AMP AMP-activated protein kinase AMP-Activated Protein Kinases - metabolism Analysis Animals Aorta - drug effects Aorta - metabolism Base Sequence Basic Medicine Biology Blood pressure Carotid Arteries - drug effects Carotid Arteries - metabolism Cell and Molecular Biology Cell- och molekylärbiologi Circulatory system Clinical Medicine Clusters Differentiation Down-Regulation - drug effects Down-Regulation - genetics Endocrinology and Diabetes Endokrinologi och diabetes Enzyme Activation - drug effects Fysiologi Intracellular signalling Kinases Klinisk medicin Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicinska och farmaceutiska grundvetenskaper Mice Mice, Inbred C57BL MicroRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Molecular Sequence Data Muscle contraction Muscle Contraction - drug effects Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - enzymology Muscles Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - enzymology Phosphorylation Phosphorylation - drug effects Physiology Portal vein Portal Vein - drug effects Portal Vein - metabolism Pressure Protein kinases Ribonucleotides - pharmacology Rodents Signal transduction Signal Transduction - drug effects Signal Transduction - genetics Smooth muscle Stress, Mechanical Transfection Veins Veins & arteries
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