Detection of JC virus-specific immune responses in a novel humanized mouse model

Progressive Multifocal Leukoencephalopathy (PML) is an often fatal disease caused by the reactivation of the JC virus (JCV). Better understanding of viral-host interactions has been hampered by the lack of an animal model. Engrafting NOD/SCID/IL-2-Rg (null) mice with human lymphocytes and thymus, we...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64313-e64313
Hauptverfasser:	Tan, Chen Sabrina, Broge, Jr, Thomas A, Seung, Edward, Vrbanac, Vlad, Viscidi, Raphael, Gordon, Jennifer, Tager, Andrew M, Koralnik, Igor J
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Analysis Animals Antibodies, Viral - blood Antigens Antigens, Differentiation - metabolism Antigens, Viral - immunology B cells Biology Bone marrow Brain research Capsid Proteins - immunology Chlorocebus aethiops Compartments COS Cells Deoxyribonucleic acid Disease Models, Animal DNA DNA, Viral - blood DNA, Viral - urine Drug dosages Encephalitis Exhaustion Gene expression Health aspects HIV Hospitals Human immunodeficiency virus Humans Immune response Immune response (cell-mediated) Immune response (humoral) Immunity, Cellular Immunity, Humoral Immunology Infection Infections Inflammatory diseases Inoculation Interleukin 2 JC Virus - genetics JC Virus - immunology Kidney - virology Kidneys Laboratory animals Leukoencephalopathy Leukoencephalopathy, Progressive Multifocal - immunology Leukoencephalopathy, Progressive Multifocal - metabolism Leukoencephalopathy, Progressive Multifocal - virology Lymphocytes Medical prognosis Medicine Mice Mice, Inbred NOD Mice, SCID Mutation Neurology PD-1 protein Programmed Cell Death 1 Receptor Progressive multifocal leukoencephalopathy Rheumatology Thymus Urine Vaccines Viral infections Virology Viruses
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