Diagnostic value of the impairment of olfaction in Parkinson's disease
Olfactory impairment is increasingly recognized as an early symptom in the development of Parkinson's disease. Testing olfactory function is a non-invasive method but can be time-consuming which restricts its application in clinical settings and epidemiological studies. Here, we investigate odo...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-05, Vol.8 (5), p.e64735-e64735 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e64735 |
|---|---|
| container_issue | 5 |
| container_start_page | e64735 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Casjens, Swaantje Eckert, Angelika Woitalla, Dirk Ellrichmann, Gisa Turewicz, Michael Stephan, Christian Eisenacher, Martin May, Caroline Meyer, Helmut E Brüning, Thomas Pesch, Beate |
| description | Olfactory impairment is increasingly recognized as an early symptom in the development of Parkinson's disease. Testing olfactory function is a non-invasive method but can be time-consuming which restricts its application in clinical settings and epidemiological studies. Here, we investigate odor identification as a supportive diagnostic tool for Parkinson's disease and estimate the performance of odor subsets to allow a more rapid testing of olfactory impairment.
Odor identification was assessed with 16 Sniffin' sticks in 148 Parkinson patients and 148 healthy controls. Risks of olfactory impairment were estimated with proportional odds models. Random forests were applied to classify Parkinson and non-Parkinson patients. Parkinson patients were rarely normosmic (identification of more than 12 odors; 16.8%) and identified on average seven odors whereas the reference group identified 12 odors and showed a higher prevalence of normosmy (31.1%). Parkinson patients with rigidity dominance had a twofold greater prevalence of olfactory impairment. Disease severity was associated with impairment of odor identification (per score point of the Hoehn and Yahr rating OR 1.87, 95% CI 1.26-2.77). Age-related impairment of olfaction showed a steeper gradient in Parkinson patients. Coffee, peppermint, and anise showed the largest difference in odor identification between Parkinson patients and controls. Random forests estimated a misclassification rate of 22.4% when comparing Parkinson patients with healthy controls using all 16 odors. A similar rate (23.8%) was observed when only the three aforementioned odors were applied.
Our findings indicate that testing odor identification can be a supportive diagnostic tool for Parkinson's disease. The application of only three odors performed well in discriminating Parkinson patients from controls, which can facilitate a wider application of this method as a point-of-care test. |
| doi_str_mv | 10.1371/journal.pone.0064735 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1352868963</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478246620</galeid><doaj_id>oai_doaj_org_article_83d938495c7d43e194a9fd2b7ddb1612</doaj_id><sourcerecordid>A478246620</sourcerecordid><originalsourceid>FETCH-LOGICAL-c758t-2f578ce3a6a21a8250f4a036b224e65316f019d48654bc1b379c11981b0d23933</originalsourceid><addsrcrecordid>eNqNkttu1DAQhi0EomXhDRBEQuJwsYvPsW-QqkJhpUpFnG4tx3Z2XRJ7sZMK3p6km1Yb1AvkC1vjb357Zn4AniK4QqREby9jn4JuVrsY3ApCTkvC7oFjJAlecgzJ_YPzEXiU8yWEjAjOH4IjTLjkEtJjcPbe602IufOmuNJN74pYF93WFb7daZ9aF7oxEptam87HUPhQfNbppw85hle5sD47nd1j8KDWTXZPpn0Bvp99-Hb6aXl-8XF9enK-NCUT3RLXrBTGEc01RlpgBmuqIeEVxtRxRhCvIZKWCs5oZVBFSmkQkgJV0GIiCVmA53vdXROzmlqQFSIMCy4kH4n1nrBRX6pd8q1Of1TUXl0HYtoonYZqG6cEsZIIKpkpLSUOSaplbXFVWlshjvCg9W56ra9aZ83QjKSbmej8Jvit2sQrRThjUo4CryeBFH_1Lneq9dm4ptHBxf7637SUWAyDWoAX_6B3VzdRGz0U4EMdh3fNKKpOaCkw5eO4F2B1BzUs61pvBr_UfojPEt7MEgamc7-7je5zVuuvX_6fvfgxZ18esFunm26bY9OPTspzkO5Bk2LOydW3TUZQjXa_6YYa7a4muw9pzw4HdJt042_yF9kR9-Y</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1352868963</pqid></control><display><type>article</type><title>Diagnostic value of the impairment of olfaction in Parkinson's disease</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Casjens, Swaantje ; Eckert, Angelika ; Woitalla, Dirk ; Ellrichmann, Gisa ; Turewicz, Michael ; Stephan, Christian ; Eisenacher, Martin ; May, Caroline ; Meyer, Helmut E ; Brüning, Thomas ; Pesch, Beate</creator><contributor>Hummel, Thomas</contributor><creatorcontrib>Casjens, Swaantje ; Eckert, Angelika ; Woitalla, Dirk ; Ellrichmann, Gisa ; Turewicz, Michael ; Stephan, Christian ; Eisenacher, Martin ; May, Caroline ; Meyer, Helmut E ; Brüning, Thomas ; Pesch, Beate ; Hummel, Thomas</creatorcontrib><description>Olfactory impairment is increasingly recognized as an early symptom in the development of Parkinson's disease. Testing olfactory function is a non-invasive method but can be time-consuming which restricts its application in clinical settings and epidemiological studies. Here, we investigate odor identification as a supportive diagnostic tool for Parkinson's disease and estimate the performance of odor subsets to allow a more rapid testing of olfactory impairment.
Odor identification was assessed with 16 Sniffin' sticks in 148 Parkinson patients and 148 healthy controls. Risks of olfactory impairment were estimated with proportional odds models. Random forests were applied to classify Parkinson and non-Parkinson patients. Parkinson patients were rarely normosmic (identification of more than 12 odors; 16.8%) and identified on average seven odors whereas the reference group identified 12 odors and showed a higher prevalence of normosmy (31.1%). Parkinson patients with rigidity dominance had a twofold greater prevalence of olfactory impairment. Disease severity was associated with impairment of odor identification (per score point of the Hoehn and Yahr rating OR 1.87, 95% CI 1.26-2.77). Age-related impairment of olfaction showed a steeper gradient in Parkinson patients. Coffee, peppermint, and anise showed the largest difference in odor identification between Parkinson patients and controls. Random forests estimated a misclassification rate of 22.4% when comparing Parkinson patients with healthy controls using all 16 odors. A similar rate (23.8%) was observed when only the three aforementioned odors were applied.
Our findings indicate that testing odor identification can be a supportive diagnostic tool for Parkinson's disease. The application of only three odors performed well in discriminating Parkinson patients from controls, which can facilitate a wider application of this method as a point-of-care test.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0064735</identifier><identifier>PMID: 23696904</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Aged ; Biology ; Coffee ; Cognition & reasoning ; Cognitive ability ; Consent ; Cross-Sectional Studies ; Diagnostic software ; Diagnostic systems ; Disease prevention ; Epidemiology ; Female ; Forests ; Humans ; Identification ; Impairment ; Male ; Mathematics ; Medical diagnosis ; Medical research ; Medicine ; Middle Aged ; Movement disorders ; Neurodegenerative diseases ; Odor ; Odorants - analysis ; Odors ; Older people ; Olfaction ; Olfaction Disorders - diagnosis ; Olfactory discrimination ; Parkinson Disease - physiopathology ; Parkinson's disease ; Parkinsons disease ; Patients ; Peppermint ; Rigidity ; Society ; Test procedures</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e64735-e64735</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Casjens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Casjens et al 2013 Casjens et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-2f578ce3a6a21a8250f4a036b224e65316f019d48654bc1b379c11981b0d23933</citedby><cites>FETCH-LOGICAL-c758t-2f578ce3a6a21a8250f4a036b224e65316f019d48654bc1b379c11981b0d23933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655992/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655992/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23696904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hummel, Thomas</contributor><creatorcontrib>Casjens, Swaantje</creatorcontrib><creatorcontrib>Eckert, Angelika</creatorcontrib><creatorcontrib>Woitalla, Dirk</creatorcontrib><creatorcontrib>Ellrichmann, Gisa</creatorcontrib><creatorcontrib>Turewicz, Michael</creatorcontrib><creatorcontrib>Stephan, Christian</creatorcontrib><creatorcontrib>Eisenacher, Martin</creatorcontrib><creatorcontrib>May, Caroline</creatorcontrib><creatorcontrib>Meyer, Helmut E</creatorcontrib><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><title>Diagnostic value of the impairment of olfaction in Parkinson's disease</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Olfactory impairment is increasingly recognized as an early symptom in the development of Parkinson's disease. Testing olfactory function is a non-invasive method but can be time-consuming which restricts its application in clinical settings and epidemiological studies. Here, we investigate odor identification as a supportive diagnostic tool for Parkinson's disease and estimate the performance of odor subsets to allow a more rapid testing of olfactory impairment.
Odor identification was assessed with 16 Sniffin' sticks in 148 Parkinson patients and 148 healthy controls. Risks of olfactory impairment were estimated with proportional odds models. Random forests were applied to classify Parkinson and non-Parkinson patients. Parkinson patients were rarely normosmic (identification of more than 12 odors; 16.8%) and identified on average seven odors whereas the reference group identified 12 odors and showed a higher prevalence of normosmy (31.1%). Parkinson patients with rigidity dominance had a twofold greater prevalence of olfactory impairment. Disease severity was associated with impairment of odor identification (per score point of the Hoehn and Yahr rating OR 1.87, 95% CI 1.26-2.77). Age-related impairment of olfaction showed a steeper gradient in Parkinson patients. Coffee, peppermint, and anise showed the largest difference in odor identification between Parkinson patients and controls. Random forests estimated a misclassification rate of 22.4% when comparing Parkinson patients with healthy controls using all 16 odors. A similar rate (23.8%) was observed when only the three aforementioned odors were applied.
Our findings indicate that testing odor identification can be a supportive diagnostic tool for Parkinson's disease. The application of only three odors performed well in discriminating Parkinson patients from controls, which can facilitate a wider application of this method as a point-of-care test.</description><subject>Age</subject><subject>Aged</subject><subject>Biology</subject><subject>Coffee</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Consent</subject><subject>Cross-Sectional Studies</subject><subject>Diagnostic software</subject><subject>Diagnostic systems</subject><subject>Disease prevention</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Forests</subject><subject>Humans</subject><subject>Identification</subject><subject>Impairment</subject><subject>Male</subject><subject>Mathematics</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Odor</subject><subject>Odorants - analysis</subject><subject>Odors</subject><subject>Older people</subject><subject>Olfaction</subject><subject>Olfaction Disorders - diagnosis</subject><subject>Olfactory discrimination</subject><subject>Parkinson Disease - physiopathology</subject><subject>Parkinson's disease</subject><subject>Parkinsons disease</subject><subject>Patients</subject><subject>Peppermint</subject><subject>Rigidity</subject><subject>Society</subject><subject>Test procedures</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkttu1DAQhi0EomXhDRBEQuJwsYvPsW-QqkJhpUpFnG4tx3Z2XRJ7sZMK3p6km1Yb1AvkC1vjb357Zn4AniK4QqREby9jn4JuVrsY3ApCTkvC7oFjJAlecgzJ_YPzEXiU8yWEjAjOH4IjTLjkEtJjcPbe602IufOmuNJN74pYF93WFb7daZ9aF7oxEptam87HUPhQfNbppw85hle5sD47nd1j8KDWTXZPpn0Bvp99-Hb6aXl-8XF9enK-NCUT3RLXrBTGEc01RlpgBmuqIeEVxtRxRhCvIZKWCs5oZVBFSmkQkgJV0GIiCVmA53vdXROzmlqQFSIMCy4kH4n1nrBRX6pd8q1Of1TUXl0HYtoonYZqG6cEsZIIKpkpLSUOSaplbXFVWlshjvCg9W56ra9aZ83QjKSbmej8Jvit2sQrRThjUo4CryeBFH_1Lneq9dm4ptHBxf7637SUWAyDWoAX_6B3VzdRGz0U4EMdh3fNKKpOaCkw5eO4F2B1BzUs61pvBr_UfojPEt7MEgamc7-7je5zVuuvX_6fvfgxZ18esFunm26bY9OPTspzkO5Bk2LOydW3TUZQjXa_6YYa7a4muw9pzw4HdJt042_yF9kR9-Y</recordid><startdate>20130516</startdate><enddate>20130516</enddate><creator>Casjens, Swaantje</creator><creator>Eckert, Angelika</creator><creator>Woitalla, Dirk</creator><creator>Ellrichmann, Gisa</creator><creator>Turewicz, Michael</creator><creator>Stephan, Christian</creator><creator>Eisenacher, Martin</creator><creator>May, Caroline</creator><creator>Meyer, Helmut E</creator><creator>Brüning, Thomas</creator><creator>Pesch, Beate</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130516</creationdate><title>Diagnostic value of the impairment of olfaction in Parkinson's disease</title><author>Casjens, Swaantje ; Eckert, Angelika ; Woitalla, Dirk ; Ellrichmann, Gisa ; Turewicz, Michael ; Stephan, Christian ; Eisenacher, Martin ; May, Caroline ; Meyer, Helmut E ; Brüning, Thomas ; Pesch, Beate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-2f578ce3a6a21a8250f4a036b224e65316f019d48654bc1b379c11981b0d23933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age</topic><topic>Aged</topic><topic>Biology</topic><topic>Coffee</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Consent</topic><topic>Cross-Sectional Studies</topic><topic>Diagnostic software</topic><topic>Diagnostic systems</topic><topic>Disease prevention</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Forests</topic><topic>Humans</topic><topic>Identification</topic><topic>Impairment</topic><topic>Male</topic><topic>Mathematics</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Odor</topic><topic>Odorants - analysis</topic><topic>Odors</topic><topic>Older people</topic><topic>Olfaction</topic><topic>Olfaction Disorders - diagnosis</topic><topic>Olfactory discrimination</topic><topic>Parkinson Disease - physiopathology</topic><topic>Parkinson's disease</topic><topic>Parkinsons disease</topic><topic>Patients</topic><topic>Peppermint</topic><topic>Rigidity</topic><topic>Society</topic><topic>Test procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Casjens, Swaantje</creatorcontrib><creatorcontrib>Eckert, Angelika</creatorcontrib><creatorcontrib>Woitalla, Dirk</creatorcontrib><creatorcontrib>Ellrichmann, Gisa</creatorcontrib><creatorcontrib>Turewicz, Michael</creatorcontrib><creatorcontrib>Stephan, Christian</creatorcontrib><creatorcontrib>Eisenacher, Martin</creatorcontrib><creatorcontrib>May, Caroline</creatorcontrib><creatorcontrib>Meyer, Helmut E</creatorcontrib><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Casjens, Swaantje</au><au>Eckert, Angelika</au><au>Woitalla, Dirk</au><au>Ellrichmann, Gisa</au><au>Turewicz, Michael</au><au>Stephan, Christian</au><au>Eisenacher, Martin</au><au>May, Caroline</au><au>Meyer, Helmut E</au><au>Brüning, Thomas</au><au>Pesch, Beate</au><au>Hummel, Thomas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic value of the impairment of olfaction in Parkinson's disease</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-16</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e64735</spage><epage>e64735</epage><pages>e64735-e64735</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Olfactory impairment is increasingly recognized as an early symptom in the development of Parkinson's disease. Testing olfactory function is a non-invasive method but can be time-consuming which restricts its application in clinical settings and epidemiological studies. Here, we investigate odor identification as a supportive diagnostic tool for Parkinson's disease and estimate the performance of odor subsets to allow a more rapid testing of olfactory impairment.
Odor identification was assessed with 16 Sniffin' sticks in 148 Parkinson patients and 148 healthy controls. Risks of olfactory impairment were estimated with proportional odds models. Random forests were applied to classify Parkinson and non-Parkinson patients. Parkinson patients were rarely normosmic (identification of more than 12 odors; 16.8%) and identified on average seven odors whereas the reference group identified 12 odors and showed a higher prevalence of normosmy (31.1%). Parkinson patients with rigidity dominance had a twofold greater prevalence of olfactory impairment. Disease severity was associated with impairment of odor identification (per score point of the Hoehn and Yahr rating OR 1.87, 95% CI 1.26-2.77). Age-related impairment of olfaction showed a steeper gradient in Parkinson patients. Coffee, peppermint, and anise showed the largest difference in odor identification between Parkinson patients and controls. Random forests estimated a misclassification rate of 22.4% when comparing Parkinson patients with healthy controls using all 16 odors. A similar rate (23.8%) was observed when only the three aforementioned odors were applied.
Our findings indicate that testing odor identification can be a supportive diagnostic tool for Parkinson's disease. The application of only three odors performed well in discriminating Parkinson patients from controls, which can facilitate a wider application of this method as a point-of-care test.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23696904</pmid><doi>10.1371/journal.pone.0064735</doi><tpages>e64735</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-05, Vol.8 (5), p.e64735-e64735 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1352868963 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Age Aged Biology Coffee Cognition & reasoning Cognitive ability Consent Cross-Sectional Studies Diagnostic software Diagnostic systems Disease prevention Epidemiology Female Forests Humans Identification Impairment Male Mathematics Medical diagnosis Medical research Medicine Middle Aged Movement disorders Neurodegenerative diseases Odor Odorants - analysis Odors Older people Olfaction Olfaction Disorders - diagnosis Olfactory discrimination Parkinson Disease - physiopathology Parkinson's disease Parkinsons disease Patients Peppermint Rigidity Society Test procedures |
| title | Diagnostic value of the impairment of olfaction in Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T07%3A43%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diagnostic%20value%20of%20the%20impairment%20of%20olfaction%20in%20Parkinson's%20disease&rft.jtitle=PloS%20one&rft.au=Casjens,%20Swaantje&rft.date=2013-05-16&rft.volume=8&rft.issue=5&rft.spage=e64735&rft.epage=e64735&rft.pages=e64735-e64735&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0064735&rft_dat=%3Cgale_plos_%3EA478246620%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1352868963&rft_id=info:pmid/23696904&rft_galeid=A478246620&rft_doaj_id=oai_doaj_org_article_83d938495c7d43e194a9fd2b7ddb1612&rfr_iscdi=true |