Complement C5 activation during influenza A infection in mice contributes to neutrophil recruitment and lung injury

Influenza virus A (IAV) causes annual epidemics and intermittent pandemics that affect millions of people worldwide. Potent inflammatory responses are commonly associated with severe cases of IAV infection. The complement system, an important mechanism of innate and humoral immune responses to infec...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e64443-e64443
Hauptverfasser:	Garcia, Cristiana C, Weston-Davies, Wynne, Russo, Remo C, Tavares, Luciana P, Rachid, Milene A, Alves-Filho, José C, Machado, Alexandre V, Ryffel, Bernhard, Nunn, Miles A, Teixeira, Mauro M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Anaphylatoxin C5a Animal models Animals Avian flu Biology Bronchoalveolar lavage Bronchus Cell activation Complement Complement activation Complement C5 - metabolism Complement component C5 Complement component C5a Epidemics Health aspects Humans Immune response (humoral) Immunoglobulin M Infections Infiltration Inflammation Influenza Influenza A Influenza A virus - immunology Influenza A virus - pathogenicity Influenza viruses Injuries Leukocytes Lung Injury - etiology Lung Injury - virology Lungs Macrophages Male Medical research Medicine Mice Mice, Inbred C57BL Mitochondrial DNA Neutralization Neutrophil Infiltration - physiology Neutrophils Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - virology Pandemics Pathology Proteins Recruitment Rodents Sepsis Virions Viruses White blood cells
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