HMGB1 accelerates alveolar epithelial repair via an IL-1β- and αvβ6 integrin-dependent activation of TGF-β1

High mobility group box 1 (HMGB1) protein is a danger-signaling molecule, known to activate an inflammatory response via TLR4 and RAGE. HMGB1 can be either actively secreted or passively released from damaged alveolar epithelial cells. Previous studies have shown that IL-1β, a critical mediator acut...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63907-e63907
Hauptverfasser:	Pittet, Jean-François, Koh, Hidefumi, Fang, Xiaohui, Iles, Karen, Christiaans, Sarah, Anjun, Naseem, Wagener, Brant M, Park, Dae Won, Zmijewski, Jaroslaw W, Matthay, Michael A, Roux, Jérémie
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Activation Alveoli Anesthesiology Animals Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Biology Cell adhesion & migration Cell culture Cells, Cultured Cytokines Departments Epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelium Growth factors Hazards High mobility group proteins HMGB1 protein HMGB1 Protein - genetics HMGB1 Protein - metabolism Humans IL-1β Immunoglobulins Inflammation Inflammatory response Injuries Integrins - genetics Integrins - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Kinases Lungs MAP kinase Medicine Monolayers Neutrophils Proteins Pulmonary Alveoli - cytology Pulmonary fibrosis R&D Rats Repair Research & development RhoA protein Signaling TLR4 protein Toll-like receptors Transforming Growth Factor beta1 - genetics Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Wound healing Wound Healing - genetics Wound Healing - physiology
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