The positive inotropic effect of pyruvate involves an increase in myofilament calcium sensitivity

Pyruvate is a metabolic fuel that is a potent inotropic agent. Despite its unique inotropic and antioxidant properties, the molecular mechanism of its inotropic mechanism is still largely unknown. To examine the inotropic effect of pyruvate in parallel with intracellular calcium handling under near...

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Veröffentlicht in:	PloS one 2013-05, Vol.8 (5), p.e63608-e63608
Hauptverfasser:	Torres, Carlos A A, Varian, Kenneth D, Canan, Cynthia H, Davis, Jonathan P, Janssen, Paul M L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Biology Calcium Calcium (intracellular) Calcium (reticular) Calcium - metabolism Chemistry Cyclopiazonic acid Fura-2 Heart Heart diseases Heart failure Hypoxia Infusion Laboratory animals Male Medicine Metabolism Muscle Contraction - drug effects Myofibrils - drug effects Myofibrils - metabolism Myofibrils - physiology pH effects Phosphorylation Physiological aspects Physiological effects Physiology Potassium Pyruvic acid Pyruvic Acid - pharmacology Rabbits Rodents Ryanodine Sarcoplasmic reticulum Sarcoplasmic Reticulum - drug effects Sarcoplasmic Reticulum - metabolism Sensitivity Sensitivity analysis Sensitizing Thapsigargin
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