Reference values of impulse oscillometric lung function indices in adults of advanced age
Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry. Only few reference equations are available for Caucasians, none of them covering the old age....
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| creator | Schulz, Holger Flexeder, Claudia Behr, Jürgen Heier, Margit Holle, Rolf Huber, Rudolf M Jörres, Rudolf A Nowak, Dennis Peters, Annette Wichmann, H-Erich Heinrich, Joachim Karrasch, Stefan |
| description | Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry. Only few reference equations are available for Caucasians, none of them covering the old age. Here, we provide reference equations up to advanced age and compare them with currently available equations.
IOS was performed in a population-based sample of 1990 subjects, aged 45-91 years, from KORA cohorts (Augsburg, Germany). From those, 397 never-smoking, lung healthy subjects with normal spirometry were identified and sex-specific quantile regression models with age, height and body weight as predictors for respiratory system impedance, resistance, reactance, and other parameters of IOS applied.
Women (n = 243) showed higher resistance values than men (n = 154), while reactance at low frequencies (up to 20 Hz) was lower (p |
| doi_str_mv | 10.1371/journal.pone.0063366 |
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IOS was performed in a population-based sample of 1990 subjects, aged 45-91 years, from KORA cohorts (Augsburg, Germany). From those, 397 never-smoking, lung healthy subjects with normal spirometry were identified and sex-specific quantile regression models with age, height and body weight as predictors for respiratory system impedance, resistance, reactance, and other parameters of IOS applied.
Women (n = 243) showed higher resistance values than men (n = 154), while reactance at low frequencies (up to 20 Hz) was lower (p<0.05). A significant age dependency was observed for the difference between resistance values at 5 Hz and 20 Hz (R5-R20), the integrated area of low-frequency reactance (AX), and resonant frequency (Fres) in both sexes whereas reactance at 5 Hz (X5) was age dependent only in females. In the healthy subjects (n = 397), mean differences between observed values and predictions for resistance (5 Hz and 20 Hz) and reactance (5 Hz) ranged between -1% and 5% when using the present model. In contrast, differences based on the currently applied equations (Vogel & Smidt 1994) ranged between -34% and 76%. Regarding our equations the indices were beyond the limits of normal in 8.1% to 18.6% of the entire KORA cohort (n = 1990), and in 0.7% to 9.4% with the currently applied equations.
Our study provides up-to-date reference equations for IOS in Caucasians aged 45 to 85 years. We suggest the use of the present equations particularly in advanced age in order to detect airway dysfunction.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0063366</identifier><identifier>PMID: 23691036</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adults ; Age ; Aged ; Aged, 80 and over ; Analysis ; Biology ; Body weight ; Cohort Studies ; Diagnostic systems ; Engineering ; Environmental health ; Epidemiology ; Ethics ; Female ; Females ; Humans ; Lung diseases ; Lungs ; Male ; Mathematical models ; Medical research ; Medicine ; Middle Aged ; Normal distribution ; Obesity ; Oscillometry - methods ; Patients ; Population ; Pulmonary function tests ; Reactance ; Reference Standards ; Regression analysis ; Regression models ; Respiration ; Respiratory function ; Respiratory Function Tests ; Respiratory system ; Respiratory tract ; Smoking ; Studies</subject><ispartof>PloS one, 2013-05, Vol.8 (5), p.e63366-e63366</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Schulz et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Schulz et al 2013 Schulz et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-27fab51061ff5e7c59392c7dcb8b2982edaa4f1d78b3acc5f14f9843b48636ad3</citedby><cites>FETCH-LOGICAL-c692t-27fab51061ff5e7c59392c7dcb8b2982edaa4f1d78b3acc5f14f9843b48636ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655177/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655177/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23691036$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Watz, Henrik</contributor><creatorcontrib>Schulz, Holger</creatorcontrib><creatorcontrib>Flexeder, Claudia</creatorcontrib><creatorcontrib>Behr, Jürgen</creatorcontrib><creatorcontrib>Heier, Margit</creatorcontrib><creatorcontrib>Holle, Rolf</creatorcontrib><creatorcontrib>Huber, Rudolf M</creatorcontrib><creatorcontrib>Jörres, Rudolf A</creatorcontrib><creatorcontrib>Nowak, Dennis</creatorcontrib><creatorcontrib>Peters, Annette</creatorcontrib><creatorcontrib>Wichmann, H-Erich</creatorcontrib><creatorcontrib>Heinrich, Joachim</creatorcontrib><creatorcontrib>Karrasch, Stefan</creatorcontrib><creatorcontrib>KORA Study Group</creatorcontrib><creatorcontrib>the KORA Study Group</creatorcontrib><title>Reference values of impulse oscillometric lung function indices in adults of advanced age</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry. Only few reference equations are available for Caucasians, none of them covering the old age. Here, we provide reference equations up to advanced age and compare them with currently available equations.
IOS was performed in a population-based sample of 1990 subjects, aged 45-91 years, from KORA cohorts (Augsburg, Germany). From those, 397 never-smoking, lung healthy subjects with normal spirometry were identified and sex-specific quantile regression models with age, height and body weight as predictors for respiratory system impedance, resistance, reactance, and other parameters of IOS applied.
Women (n = 243) showed higher resistance values than men (n = 154), while reactance at low frequencies (up to 20 Hz) was lower (p<0.05). A significant age dependency was observed for the difference between resistance values at 5 Hz and 20 Hz (R5-R20), the integrated area of low-frequency reactance (AX), and resonant frequency (Fres) in both sexes whereas reactance at 5 Hz (X5) was age dependent only in females. In the healthy subjects (n = 397), mean differences between observed values and predictions for resistance (5 Hz and 20 Hz) and reactance (5 Hz) ranged between -1% and 5% when using the present model. In contrast, differences based on the currently applied equations (Vogel & Smidt 1994) ranged between -34% and 76%. Regarding our equations the indices were beyond the limits of normal in 8.1% to 18.6% of the entire KORA cohort (n = 1990), and in 0.7% to 9.4% with the currently applied equations.
Our study provides up-to-date reference equations for IOS in Caucasians aged 45 to 85 years. We suggest the use of the present equations particularly in advanced age in order to detect airway dysfunction.</description><subject>Adults</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis</subject><subject>Biology</subject><subject>Body weight</subject><subject>Cohort Studies</subject><subject>Diagnostic systems</subject><subject>Engineering</subject><subject>Environmental health</subject><subject>Epidemiology</subject><subject>Ethics</subject><subject>Female</subject><subject>Females</subject><subject>Humans</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Normal distribution</subject><subject>Obesity</subject><subject>Oscillometry - methods</subject><subject>Patients</subject><subject>Population</subject><subject>Pulmonary function tests</subject><subject>Reactance</subject><subject>Reference Standards</subject><subject>Regression analysis</subject><subject>Regression models</subject><subject>Respiration</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Respiratory system</subject><subject>Respiratory 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values of impulse oscillometric lung function indices in adults of advanced age</title><author>Schulz, Holger ; Flexeder, Claudia ; Behr, Jürgen ; Heier, Margit ; Holle, Rolf ; Huber, Rudolf M ; Jörres, Rudolf A ; Nowak, Dennis ; Peters, Annette ; Wichmann, H-Erich ; Heinrich, Joachim ; Karrasch, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-27fab51061ff5e7c59392c7dcb8b2982edaa4f1d78b3acc5f14f9843b48636ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adults</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis</topic><topic>Biology</topic><topic>Body weight</topic><topic>Cohort Studies</topic><topic>Diagnostic systems</topic><topic>Engineering</topic><topic>Environmental health</topic><topic>Epidemiology</topic><topic>Ethics</topic><topic>Female</topic><topic>Females</topic><topic>Humans</topic><topic>Lung diseases</topic><topic>Lungs</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Middle Aged</topic><topic>Normal distribution</topic><topic>Obesity</topic><topic>Oscillometry - methods</topic><topic>Patients</topic><topic>Population</topic><topic>Pulmonary function tests</topic><topic>Reactance</topic><topic>Reference Standards</topic><topic>Regression analysis</topic><topic>Regression models</topic><topic>Respiration</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Respiratory system</topic><topic>Respiratory tract</topic><topic>Smoking</topic><topic>Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schulz, Holger</creatorcontrib><creatorcontrib>Flexeder, Claudia</creatorcontrib><creatorcontrib>Behr, Jürgen</creatorcontrib><creatorcontrib>Heier, Margit</creatorcontrib><creatorcontrib>Holle, 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Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schulz, Holger</au><au>Flexeder, Claudia</au><au>Behr, Jürgen</au><au>Heier, Margit</au><au>Holle, Rolf</au><au>Huber, Rudolf M</au><au>Jörres, Rudolf A</au><au>Nowak, Dennis</au><au>Peters, Annette</au><au>Wichmann, H-Erich</au><au>Heinrich, Joachim</au><au>Karrasch, Stefan</au><au>Watz, Henrik</au><aucorp>KORA Study Group</aucorp><aucorp>the KORA Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reference values of impulse oscillometric lung function indices in adults of advanced age</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-05-15</date><risdate>2013</risdate><volume>8</volume><issue>5</issue><spage>e63366</spage><epage>e63366</epage><pages>e63366-e63366</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Impulse oscillometry (IOS) is a non-demanding lung function test. Its diagnostic use may be particularly useful in patients of advanced age with physical or mental limitations unable to perform spirometry. Only few reference equations are available for Caucasians, none of them covering the old age. Here, we provide reference equations up to advanced age and compare them with currently available equations.
IOS was performed in a population-based sample of 1990 subjects, aged 45-91 years, from KORA cohorts (Augsburg, Germany). From those, 397 never-smoking, lung healthy subjects with normal spirometry were identified and sex-specific quantile regression models with age, height and body weight as predictors for respiratory system impedance, resistance, reactance, and other parameters of IOS applied.
Women (n = 243) showed higher resistance values than men (n = 154), while reactance at low frequencies (up to 20 Hz) was lower (p<0.05). A significant age dependency was observed for the difference between resistance values at 5 Hz and 20 Hz (R5-R20), the integrated area of low-frequency reactance (AX), and resonant frequency (Fres) in both sexes whereas reactance at 5 Hz (X5) was age dependent only in females. In the healthy subjects (n = 397), mean differences between observed values and predictions for resistance (5 Hz and 20 Hz) and reactance (5 Hz) ranged between -1% and 5% when using the present model. In contrast, differences based on the currently applied equations (Vogel & Smidt 1994) ranged between -34% and 76%. Regarding our equations the indices were beyond the limits of normal in 8.1% to 18.6% of the entire KORA cohort (n = 1990), and in 0.7% to 9.4% with the currently applied equations.
Our study provides up-to-date reference equations for IOS in Caucasians aged 45 to 85 years. We suggest the use of the present equations particularly in advanced age in order to detect airway dysfunction.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23691036</pmid><doi>10.1371/journal.pone.0063366</doi><tpages>e63366</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2013-05, Vol.8 (5), p.e63366-e63366 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1351911907 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS) Journals Open Access; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adults Age Aged Aged, 80 and over Analysis Biology Body weight Cohort Studies Diagnostic systems Engineering Environmental health Epidemiology Ethics Female Females Humans Lung diseases Lungs Male Mathematical models Medical research Medicine Middle Aged Normal distribution Obesity Oscillometry - methods Patients Population Pulmonary function tests Reactance Reference Standards Regression analysis Regression models Respiration Respiratory function Respiratory Function Tests Respiratory system Respiratory tract Smoking Studies |
| title | Reference values of impulse oscillometric lung function indices in adults of advanced age |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T19%3A19%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Reference%20values%20of%20impulse%20oscillometric%20lung%20function%20indices%20in%20adults%20of%20advanced%20age&rft.jtitle=PloS%20one&rft.au=Schulz,%20Holger&rft.aucorp=KORA%20Study%20Group&rft.date=2013-05-15&rft.volume=8&rft.issue=5&rft.spage=e63366&rft.epage=e63366&rft.pages=e63366-e63366&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0063366&rft_dat=%3Cgale_plos_%3EA478262283%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1351911907&rft_id=info:pmid/23691036&rft_galeid=A478262283&rft_doaj_id=oai_doaj_org_article_974bb04dc0af4ef98edbe8cfbb209877&rfr_iscdi=true |